Ph染色体阳性成人急性B淋巴细胞白血病的免疫表型特征

目的：为了解Ph染色体阳性（Ph^ )成人急性B淋巴细胞白血病（B－ALL）的免疫表型特征。方法：对78例初治成人B－ALL形态学（M）免疫学（I）细胞遗传学（C）分型结果进行分析。结果：Ph^ 的B－ALL占25例（32．1％），其中伴髓系抗原（CD13或CD33）表达（My^ ）有14例（56．0％），CD10和CD19均高表达，伴淋系抗原（CD2或CD3或CD7）表达（Ly^ ）有3例（12．0％），CD34阳性17例（68．0％）。对于Ph染色体阴性（Ph^-)的病例，My^ 有12例，占22.6%，而Ly^ 和CD34阳性的病例分别占3．8％和83．0％。经分析发现,Ly^ 和CD34在Ph^ 和Ph^ 的病例中的阳性率差异无显著性。而Ph^ 的成人B－ALL伴My^ 高于Ph^-的成人B－ALL，且差异具有显著性。结论 成人Ph^ B－ALL通常伴My^ 、CD34表达。Ph^ 与My^ 之间可能具有一定的联系，影响成人B－ALL的预后。

Immunophenotyic Features of Ph Chromosome Positive Adult B Cell Acute Lymphoblastic Leukemia

Objective To study the immunophenotypic features of Ph Chromosome positive(Ph +) adult B cell acute lymphoblastic leukemia (B-ALL).Methods Morphologic/cytochemistric,immunophenotypic and cytogenetic(MIC) examinations were preformed in 78 previously untreated adult B-ALL.Results The 25 patients(32 1%) were Ph + among 78 patients.The 14 patients was myeloid associated antigen(CD13,CD33) positive among 25 patients with Ph + B-ALL.The myeloid antigen expression was higher in Ph + cases than Ph - B-ALL.There were no difference in the expression of CD34 or T lymphoid antigen between Ph + and Ph - B-ALL.Conclusion Patients with adult Ph + B-ALL are usually myeloid antigen?CD34 expression.The myloid antigen expression is maybe associated with Ph + in adult B-ALL.