Effect of cytokines (G-CSF and SCF) on stromal precursor cells

Repeated injections of hemopoietic cytokines (granulocyte colony-stimulating factor and stem-cell factor) to normal mice increase the content of bone marrow stromal precursors, which are capable of transferring hemopoietic microenvironment; cytokines have no effect on osteogenic potencies of stromal precursors. In contrast, injection of granulocyte colonystimulating factor during organization of a hemopoietic microenvironment considerably decreases the number of stromal precursors in the ectopic focus. The role of these stromal effects of cytokines in cytokine-induced mobilization of stem cells from the bone marrow into circulation remains unclear. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 204–206, February, 1998