Impact of Obesity and Body Fat Distribution on Survival After Pancreaticoduodenectomy for Pancreatic Adenocarcinoma |
| |
Authors: | Sébastien Gaujoux MD Javiera Torres MD Sara Olson PhD Corrine Winston MD Mithat Gonen PhD Murray F. Brennan MD David S. Klimstra MD Michael D’Angelica MD Ronald DeMatteo MD Yuman Fong MD Michael House MD William Jarnagin MD Robert C. Kurtz MD Peter J. Allen MD |
| |
Affiliation: | Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. |
| |
Abstract: | Background Epidemiologic studies have reported a positive correlation between body mass index (BMI) and pancreatic cancer risk, but clinical relevance of obesity and/or body fat distribution on tumor characteristics and cancer-related outcome remain controversial. We sought to assess the influence of obesity and body fat distribution on pathologic characteristics and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Methods Demographic and biometric data were collected on 328 patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. In a subset of patients, pancreatic fatty infiltration and fibrosis were assessed pathologically, and visceral fat area (VFA) was evaluated. Influence of BMI and body fat distribution on tumor characteristics and survival were evaluated. Results A significant positive correlation between BMI and VFA was observed, with a wide range of VFA value within each BMI class. According to BMI or VFA distribution, there were no significant differences in patient characteristics, intraoperative or perioperative outcome, or pathologic characteristics, with the exception of significantly higher blood loss in patients with an increased body weight or VFA. Unadjusted overall and disease-free survival between BMI class and VFA quartile were not significantly different. Conclusions In this study, obesity and body fat distribution were not correlated with specific tumor characteristics or cancer-related outcome. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|