| 动态血压监测评价卡维地洛和美托洛尔的降压效应 |
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| 引用本文： | 王杰萍,杨明,杜雪平,王青,韩凌,潘国忠,赵燕.动态血压监测评价卡维地洛和美托洛尔的降压效应[J].高血压杂志,2006(9). |
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| 作者姓名： | 王杰萍 杨明 杜雪平 王青 韩凌 潘国忠 赵燕 |
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| 作者单位： | 首都医科大学附属复兴医院心脏中心 北京100038 |
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| 摘 要： | 目的结合动态血压监测(ABPM)方法评价卡维地洛与美托洛尔对轻、中度高血压的降压效应。方法高血压患者78例随机分为卡维地洛组(n=39)和美托洛尔组(n=39)。分别给予卡维地洛(25~50mg/d,1次/d)和美托洛尔(100~200mg/d,2次/d),治疗12周。观察服药前及服药后12周末的24h、白昼、夜间及各时点的动态血压变化及谷/峰比。结果卡维地洛组和美托洛尔组服药前、服药治疗后12周末的24h、白昼、夜间的平均收缩压、舒张压明显下降,有显著性差异(P<0.05或<0.01)。卡维地洛组服药后12周末各时点收缩压、舒张压较服药前明显下降,有显著性差异(P<0.05)。美托洛尔组服药后12周末各时点收缩压、舒张压较服药前下降,但服药后的第23~24h夜间血压下降不明显(P>0.05)。两组治疗后平均收缩压(SBP)和平均舒张压(DBP)的谷/峰比(T/P值)分别是63%/57%,和59%/51%。结论卡维地洛可维持24h平稳降压;美托洛尔仅能维持22h内血压下降;两者均有满意的谷/峰比。
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| 关 键 词： | 卡维地洛 美托洛尔 动态血压监测 |
Efficacy of Carvedilol vs Metoprolol on Blood Pressure in Patients with Essential Hypertension |
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| WANG Jie-ping,YANG Ming,DU Xue-ping,WANG Qing,HUANG Ling,PAN Guo-zhong,ZHAO Yan. Heart Center,Fu Xing Hospital Affiliated to the Capital Medical University,Beijing ,China.Efficacy of Carvedilol vs Metoprolol on Blood Pressure in Patients with Essential Hypertension[J].Chinese Journal of Hypertension,2006(9). |
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| Authors: | WANG Jie-ping YANG Ming DU Xue-ping WANG Qing HUANG Ling PAN Guo-zhong ZHAO Yan Heart Center Fu Xing Hospital Affiliated to the Capital Medical University Beijing China |
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| Institution: | WANG Jie-ping,YANG Ming,DU Xue-ping,WANG Qing,HUANG Ling,PAN Guo-zhong,ZHAO Yan. Heart Center,Fu Xing Hospital Affiliated to the Capital Medical University,Beijing 100038,China |
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| Abstract: | |
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| Keywords: | Carvedilol Metoprolol Ambulatory blood pressure monitoring |
| 本文献已被 CNKI 等数据库收录！ |
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