肺心病患者血浆CGRP与ET-1的变化

本文通过对35例肺心病患者心导管检查分别于急性发作期和缓解期二次测定血流动力学指标,同时用放免法测定其血浆CGRP、ET-1水平。结果表明,肺心病急性发作期CGRP、ET-1及PAPM、PVR均显著高于缓解期和对照组(p<0,01)。缓解期与对照组比较无明显变化(p>0.05);吸30％氧60分钟,CGRP上升而ET-1下降,并与PAPM,paO_2存在明显相关性。由此推测ET-1水平的升高和CGRP水平的降低可能是肺动脉压力升高的重要原因。因此,积极改善缺氧,降低血浆ET-1水平,提高CGRP水平对防治肺心病肺动脉高压有重要意义。

PLASMA CALCITONIN GENE-RELATED PEPTIDE AND ENDOTHELIN-1 LEVELS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Plasma calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1) levels were measured with radioimmunoassay in 35 cases of chronic obstructive pulmonary disease (COPD) both during acute exacerbations and remissions and palmonary circulation haemodynamics were studied with cardiac catheterization simultaneously. Result: CGRP and ET-1 levels and mean pulmonary arterial pressure (PAPM) in acute exacerbations were significantly higher than those of the controls and during remissions(p<0.0l). After breathing 30% O2 for 60 minutes the level of CGRP went up notably but that of EL-l decreased remarkably. They had significant correlation with PAPM and PaO2. These results suggested that low level of CGRP and high level of ET-1 might induce pulmonary hypertension. Correcting hypoxia and keeping the balance of CGRP and ET-1 are the ways to prevent and treat the hypoxic pulmonary hypertension.