| 血红素加氧酶-1及其与重症胰腺炎之间关系的研究进展 |
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| 引用本文： | 王志威,毛恩强. 血红素加氧酶-1及其与重症胰腺炎之间关系的研究进展[J]. 国际外科学杂志, 2010, 37(2). DOI: 10.3760/cma.j.issn.1673-4203.2010.02.016 |
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| 作者姓名： | 王志威 毛恩强 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院外科ICU,上海,200025;上海交通大学医学院附属瑞金医院外科ICU,上海,200025 |
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| 摘 要： | 近年来,血红素加氧酶-1(heme oxygenase-1,HO-1)已经成为危重病及其他许多领域的研究热点.HO-1通过分解血红素而产生的一氧化碳,胆绿素和胆红素,及亚铁离子可以减轻炎性介质反应,拮抗细胞氧化性损伤和细胞应激从而发挥细胞保护性作用.而在对重症胰腺炎(severe acute pancreatitis,SAP)的研究中,人们已经认识到拮抗炎症因子的过度释放是提高胰腺炎疗效的重要环节.本文就HO-1及其与SAP之间关系的研究进展做一综述.
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| 关 键 词： | 血红素加氧酶-1 重症胰腺炎 |
Hemo oxygenase-1 and its relationship with svere acute pancreatitis |
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| WANG Zhi-wei,MAO En-qiang. Hemo oxygenase-1 and its relationship with svere acute pancreatitis[J]. International Journal of Surgery, 2010, 37(2). DOI: 10.3760/cma.j.issn.1673-4203.2010.02.016 |
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| Authors: | WANG Zhi-wei MAO En-qiang |
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| Abstract: | Recently, heme oxygenase-1 (HO-1) has been emphasized in the area of intensive care unit (ICU) and other domains. HO-1 can catalyze the decomposition of heine and the products of its enzymatic activity, including carbon monoxide, biliverdin, and bilirubin and ferritin can play a significant cytoprotec-tive role in antagonizing inflammation, protecting cells from oxidative injury and cellular stresses. In the re-search of severe acute pancreatitis (SAP), researchers have realized that it is of great importance to antago-nize the overflow of cytokines in order to improve the therapeutic effect of SAP. In this article, we give a re-view of the research progress of HO-1 and its relationship with SAP. |
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| Keywords: | Heme oxygenase-1 Pancreatitis Acute necrotizing |
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