| 灯盏花素缓释滴丸的制备及其体外释放特性的研究 |
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| 引用本文： | 刘宏,杨祥良,周林珠,王影,汤韧,徐辉碧.灯盏花素缓释滴丸的制备及其体外释放特性的研究[J].药学服务与研究,2004,4(1):30-32. |
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| 作者姓名： | 刘宏 杨祥良 周林珠 王影 汤韧 徐辉碧 |
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| 作者单位： | 1. 广州军区武汉总医院药剂科,武汉,430070
2. 华中科技大学药物研究所,武汉,430074 |
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| 摘 要： | 目的：研究灯盏花素缓释滴丸的制备方法及其体外释放特征。方法：通过固体分散技术，以硬脂酸为骨架材料，以聚乙二醇-6000为致孔剂，通过选用适当的药物与辅料比，制得具有良好缓释效果的灯盏花素缓释滴丸。采用转篮法研究其体外释放特征。结果：固体分散辅料与缓释辅料的联合应用可制得外观圆整、质地均匀的灯盏花素缓释滴丸，其体外释药行为可由Higuchi方程拟合,方程为Q=13.00 29.60t^1/2。结论：所制得的灯盏花素缓释滴丸具有良好的缓释效果。
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| 关 键 词： | 灯盏花素缓释滴丸 迟效制剂 Higuchi方程 制备方法 体外释放特征 中药制剂 |
| 文章编号： | 1671-2838(2004)01-0030-03 |
| 修稿时间： | 2003年8月11日 |
Preparation and the in vitro release characteristics of scutellarin sustained-release dropping pills |
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| LIU Hong,YANG Xiang-Liang,ZHOU Lin-Zhu,WANG Ying,TANG Ren,XU Hui-Bi.Preparation and the in vitro release characteristics of scutellarin sustained-release dropping pills[J].Pharmaceutical Care and Research,2004,4(1):30-32. |
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| Authors: | LIU Hong YANG Xiang-Liang ZHOU Lin-Zhu WANG Ying TANG Ren XU Hui-Bi |
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| Abstract: | Objective: To study the preparation and the in vitro release characteristics of scutellarin sustained-release dropping pills (Scu SDP). Methods: Scu SDP were prepared by solid dispersion method using stearic acid as an eroding matrix and PEG-6000 as a pore-forming agent. Its release characteristics were studied by rotating basket. Results: Rounded and homogeneous Scu SDP were prepared by the combined use of solid dispersion material and sustained-release material. The drug release in vitro followed the Higuchi equation Q= 13. 00 + 29. 60 t1 2. Conclusion: Scu SDP is an ideal sustained-release agent. |
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| Keywords: | scutellarin delayed-action preparations dropping pills Higuchi equation |
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