三维适形放射治疗联合吉西他滨与替加氟化学治疗对局部晚期胰腺癌的疗效

目的：评价三维适形放射治疗（three dimensional conformal radiation therapy,3DCRT）联合吉西他滨与替加氟治疗局部晚期胰腺癌的疗效及安全性.方法：对35例经病理检查证实或符合临床诊断标准的局部晚期胰腺癌患者,行3DCRT,180cGy/次,共28次（5.5周内）,总剂量为5040 cGy;同时第1天及第8天静脉滴注吉西他滨（1000 mg/m2）,第1～5天静脉滴注替加氟（1000 mg/d）;每4周为1个周期,至少2个周期,治疗结束4周后评价疗效及安全性.结果：35例患者均完成联合治疗.治疗有效率为37.1％（13/35）,肿瘤控制率为71.4％（25/35）.最常见的不良反应为恶心（26/35,74.3％）,无3度及以上骨髓抑制,患者可耐受所有不良反应.结论：3DCRT同步吉西他滨联合替加氟治疗局部晚期胰腺癌疗效较好,患者能够耐受其不良反应.

Efficacy of Three-Dimensional Conformal Radiation Therapy Combined with Gemcitabine and Tegafur in Patients with Locally Advanced Pancreatic Cancer

Objective：To evaluate the efficacy and safety of three dimensional conformal radiation therapy （3DCRT） combined with gemcitabine and tegafur for locally advanced pancreatic cancer （LAPC）.Methods：A total of 35 LAPC patients confirmed pathologically or diagnosed clinically were selected.They were treated with 3DCRT.A total dose of 5040 cGy（28 times within 5.5 weeks） was applied by daily fractions of 180cGy.In the meantime,gemcitabine 1000 mg/m2 was administered intravenously on day 1 and day 8 and tegafur 1000 mg/d was administered intravenously on day 1-5.At least 2 cycles of chemotherapy were given,with 4 weeks in a cycle.The efficacy and safety were evaluated after 4 weeks of treatment.Results：A total of 35 patients were included for evaluation of efficacy and toxicity.The effective rate and disease control rate were 37.1％ and 71.4％,respectively.The most common toxic reaction during concurrent radiotherapy was nausea （26/35,74.3％）.There was no grade 3 or above myelosuppression.All toxicities were tolerable and transient.Conclusions：3DCRT combined with gemcitabine and tegafur for LAPC is effective,and the toxicities can be tolerated by patients.