湖北省襄阳市孕妇产前筛查情况调查

目的：对湖北省襄阳市孕妇进行孕中期产前筛查,评价该地区缺陷胎儿的发生情况.方法：2006年1月-2012年12月对湖北省襄阳市14 709例妊娠15～20周的孕妇采用血清学筛查及超声诊断,随访直至分娩;对妊娠结局进行系统评估.结果：该地区孕妇的产前筛查率从2006年的18.59％上升至2012年的83.20％,筛查对象随访率88.50％,高风险孕妇检出率6.17％（907/14709）,其中唐氏综合征（Down,s syndrome,DS）检出率为5.00％ （736/14709）,18-三体综合征检出率为0.33％（48/14709）,神经管缺陷（neural tube defects,NTD）检出率为0.84％（123/14709）.结论：产前筛查对预防有先天畸形和遗传性疾病胎儿的出生、提高人口素质具有重大意义.

Observational Research on Prenatal Screening of Pregnant Women in Xiangyang City,Hubei Province

Objective：To screen the pregnant women in Xiangyang City,Hubei Province during mid-term pregnancy and to evaluate the occurrence of fetus defects in this area.Methods：This study recruited 14 709 pregnant women at 15-20 weeks gestation from January 2006 to December 2012 in Xiangyang City of Hubei Province.All of them underwent serum screening and fetal ultrasound screening.They have been followed up until delivery,and pregnancy outcomes were evaluated.Results：The prenatal screening rate raised from 18.59％ in 2006 to 83.20％ in 2012.The follow up rate of screening objects was 88.50％.The study screened out 907 cases with high-risk,and the positive rate was 6.17％ （907/14 709）.The detection rate of Down＇s Syndrome （DS） was 5.00％ （736/14 709） ; the rate of 18-trisomy syndrome was 0.33％ （48/14 709）,and the rate of neural tube defects （NTD） was 0.84％ （123/14 709）.Conclusions：Prenatal screening plays an important role in preventing the birth of fetus defects and improving the population quality.