同步放化疗对维吾尔族妇女晚期宫颈癌患者的疗效分析

目的：探讨以顺铂为基础的同步放化疗对维吾尔族妇女晚期宫颈癌患者的疗效.方法：2008年1月-2010年1月新疆维吾尔自治区喀什地区第二人民医院收治146例维吾尔族晚期宫颈癌患者,分为研究组和对照组.研究组（n=77）患者采用以顺铂为基础的化学治疗联合同步放射治疗;对照组（n=69）采用单纯放射治疗,观察2组患者近期治疗总有效率及1、2年生存率,并比较2组患者治疗后不良反应的发生率.结果：研究组患者近期治疗总有效率为85.71％（66/77）,明显高于对照组66.67％（46/69）];研究组1、2年生存率分别为72.73％（56/77）、51.95％ （40/77）,均明显高于对照组56.52％（39/69）、37.68％ （26/69）],差异均有统计学意义（P＜0.05）;2组患者治疗后不良反应的发生率差异无统计学意义.结论：以顺铂为基础的化学治疗同步放射治疗治疗维吾尔族妇女晚期宫颈癌临床疗效显著,患者预后较好,值得临床推广.

Efficacy of Concurrent Cisplatin-Based Chemotherapy and Radiotherapy in Uighur Patients with Advanced Cervical Cancer

Objective：To investigate the efficacy of concurrent cisplatin-based chemotherapy and radiotherapy in Uighur patients with advanced cervical cancer.Methods：A total of 146 Uighur patients with advanced cervical cancer in Second People＇s Hospital of Kashi in Xinjiang Uygur Autonomous Region from January 2008 to January 2010 were enrolled.Among them,77 patients in the study group were treated with concurrent cisplatin-based chemotherapy and radiotherapy while 69 patients in the control group were treated with radiotherapy alone.The recent total effective rate,one-year and two-year survival rates were observed.Furthermore,the rates of adverse reactions after treatment in the two groups were compared.Results：The total effective rate in the study group was 85.71％（66/77）,significantly higher than that in the control group66.67％（46/69）].The one-year and two-year survival rates in the study group were 72.73％ （56/77） and 51.95％ （40/77）,significantly higher than those in the control group56.52％ （39/69）,37.68％ （26/69）].The result was statistically significant（P＜0.05）.There were no significant differences in the rates of adverse reactions after treatment in the two groups.Conclusions：Concurrent cisplatinbased chemotherapy and radiotherapy has a significant curative effect on Uighur patients with advanced cervical cancer.