1 Stem Cells and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain;2 Comparative Pathology Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain;3 Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain;4 Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University of Marburg, Marburg, Germany;5 Instituto Teófilo Hernando, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;6 Experimental Oncology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain;7 Department of Internal Medicine I, Ulm University, Ulm, Germany;8 Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, UK