溃疡性结肠炎湿热内蕴型分期辨治临床研究

目的 观察溃疡性结肠炎湿热内蕴型分期辨治的临床疗效.方法 将符合标准的46例溃疡性结肠炎患者随机分为两组,研究组23例,对照组23例.研究组活动期予白头翁汤合香连丸加减方口服,并联合中药保留灌肠方外治,缓解期予参苓白术散加减方口服,若病情复发加用中药保留灌肠方;对照组予柳氮磺胺吡啶规范应用.两组疗程均为60d,疗程结束后比较两组患者的临床疗效,并分别于治疗前、治疗后第30d、治疗后第60d进行总体症状评分、单项症状评分及生活质量评分.结果 研究组总有效率非劣效于对照组;两组均能够改善总体症状评分（P〈0.05）,并且研究组在治疗后第60d对总体症状的改善优于对照组（P〈0.05）;治疗后两组患者各单项症状评分均较治疗前明显下降（P〈0.05）,治疗后60d研究组患者腹泻、脓血便、腹痛、乏力评分显著低于对照组（P〈0.05）;治疗后两组患者各生存质量指标评分均较治疗前明显升高（P〈0.05）,并且研究组各生存质量指标评分明显高于对照组（P〈0.05）.结论 中医药分期辨治能有效改善湿热内蕴型溃疡性结肠炎患者的临床症状,治疗中后期疗效尤为明显,能显著改善患者的生存质量.

Clinical Study on Staging Treatment for Ulcerative Colitis Damp-Heat Syndrome

Objective To observe the clinical curative effect of staging treatment for ulcerative colitis Damp - Heat syndrome. Methods Forty - six ulcerative colitis cases were randomly divided into study group （n = 23） and control group （ n = 23）. In the study group, patients in the active stage were treated with baitouweng decoction and xianglian pills, and in combination with Chinese medicine retain enema, patients in the remission stage were treated with sheulingbaizhu powder for oral taking. In case of the pathological condition relapsed, the retention enema was added; In the control group, the patients were given sulfasalazine tablets regularly. The course of treatment was 60 days. The clinical curative effects of two groups were compared after treatment. Overall symptom scores, single symptom score and quality of life score were recordedbefore treatment, on the 30th day, the 60th day after treatment. Results Total effective rate of study group was similar to control group ; The overall symptom scores of two groups were improved （P 〈 0. 05 ）, and the overall symptoms of the study group were improved better than that of control group on the 60th day after treatment started （ P 〈 0. 05 ） ; Each single symptom scores in both groups were decreased significantly after treatment （ P 〈 0. 05 ）, and the scores of diarrhea, pus and blood stool, abdominal pain and fatigue of the study group were significantly lower than that of control group on the 60th day of treatment （ P 〈 0. 05 ） ; The survival quality scores in both groups were significantly increased after treatment （ P 〈 0. 05 ）, and the survival quality scores of the study groups were significantly higher than control group （P 〈 0.05）. Conclusions The staging treatment of ulcerative colitis with traditional Chinese medicine can effectively improve clinical symptoms of the damp - heat syndrome, the effect of TCM present better in the middle and late stages of treatment, it could significantly improve the life quality of patients.