三阴性乳腺癌与表观遗传学研究现状

目的：探讨表观遗传修饰在三阴性乳腺癌（triplenegativebreastcancer，TNBC）检测、诊断和靶向治疗中的机制及作用。方法：应用PubMed、CNKI全文数据库及Google学术搜索等检索系统，以“乳腺癌或三阴性乳腺癌和表观遗传学或DNA甲基化”等为关键词，检索2003—01—2013-12的相关文献，共检索到英文文献1055爷，中文文献35条。纳入标准：1）TNBC癌诊断与治疗；2）表观遗传学修饰机制；3）表观遗传学对TNBC癌的意义。根据纳入标准，符合分析的文献47篇。结果：DNA甲基化、组蛋白修饰及miRNA调控在TNBC的发生、发展中扮演重要角色，通过表观遗传修饰与TNBC相关基础研究的总结，以及在已有的实验研究或临床研究的基础上进行理论推测，对TNBC的临床诊断、预后和治疗具有借鉴意义。结论：通过研究表观遗传学修饰改变在TNBC发生、发展中的作用，可为将来TNBC患者的临床治疗提供新思路。

Triple negative breast cancer and epigenetics

OBJECTIVE：To discuss the importance of epigenetics in TNBC detection,prognosis and target therapy with emphasis on mechanisms and the contributions of epigenetic to the field of caenogenesis. METHODS： Using ＂triplenegative breast cancer and the epigenetics modification＂ as keywords to retrieve related papers from 2003-01 to 2013-12 on PubMed,Sicence Direct and Google Scholar Database System and finally 1 055 English articles and 35 Chinese articles were obtained. The inclusion criteria were as follows. 1） The prognosis and therapy of triple-negative breast cancer;2） The mechanisms of epigenetics modification; 3）The significance of epigenetics modification on triple-negative breast cancer. According to this criteria 47 literatures were summarized. RESULTS： DNA methylation, histone modifications and microRNAs regulation play important roles in triple-negative breast cancer tumorigenesis,and they are important in clinical diag nosis,treatment and prognosis according to the summary of epigenetics modification in basic research and the theoretic speculation based on experimental or clinical research for triple-negative breast cancer. CONCLUSIONS： Recent findings indicate epigenetic modifications as key factors in TNBC. Future clinical therapy medical care for TNBC patients will likely depend upon a better understanding in the roles of epigenetic modifications in carcinogenesis.