桂林地区女性乳腺癌危险因素病例对照研究

目的：调查桂林地区女性乳腺癌的危险因素,探讨其病因模型,为确定当地乳腺癌高危人群及提出有效的综合防治措施提供科学依据。方法：采用以医院为基础的病例对照研究方法,分析2009-07-01-2012-10-11桂林地区3家三甲医院乳腺外科住院并经病理确诊的乳腺癌患者,对乳腺癌和对照组各302例进行生殖因素、生活方式和社会心理因素等调查。用SPSS 18.0软件进行单因素和多因素非条件Logistic回归分析。结果：初潮年龄早（OR=9.64）、流产（OR=3.27）、偏内向的性格（OR=3.14）、精神压抑（OR=17.15）、常食油炸食品（OR=7.99）、被动吸烟（OR=1.82）、熬夜（OR=3.65）和常食豆类食品（OR=0.11）8个因素最终被选入多因素非条件Logistic回归模型。结论：桂林地区女性乳腺癌主要危险因素是初潮年龄早、流产、偏内向的性格、精神压抑、常食油炸食品、被动吸烟和熬夜,而常食豆类食品是乳腺癌的保护因素。

Case control study on risk factors of female breast cancer in Guilin area

OBJECTIVE： To investigate the risk factors of female breast cancer in Guilin area and to explore its etiology model, so as to provide the scientific basis for preventive measures. METHODS： A hospital-based case-control retrospective study was conducted among 302 breast cancer patients and 302 non breast cancer patients. Structured questionnaires were used to collect information on reproductive factors, lifestyle and psychological factors et al. Univariate and multivariate unconditional Logistic regression analysis were carried out with SPSS 18.0 software. RESULTS.. Multiple analysis show that menarche age （OR = 9.64）, miscarriage （OR= 3.27）, partial introverted personality （OR= 3.14）, mental depression （OR= 17.15）, fried food （OR=7.99） ,passive smoking （OR= 1.82） and stay up lating （OR= 3.65） were risk factors of breast cancer ; bean products （OR= 0.11） was protection factor of breast cancer. CONCLUSIONS： The breast cancer risk factors in females in Guilin area mainly in elude menarche age, miscarriage, partial introverted personality, mental depression, fried food, passive smoking, stay up lating. Frequent bean products intaking is protective factor.