| 丙型肝炎病毒感染对肾移植术后影响的临床研究 |
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| 摘 要： |
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| 关 键 词： | 丙型肝炎病毒感染 肾移植 术后 临床研究 丙型肝炎 存活率 |
Hepatitis C virus infection and clinical outcome of kidney transplantation] |
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| Li-xin Yu,Zhi-peng Wang,Shao-jie Fu,Yi-bin Wang,Chu-fu Du,Jian Xu,Wen-feng Deng. Hepatitis C virus infection and clinical outcome of kidney transplantation][J]. Journal of First Military Medical University, 2004, 24(6): 682-684 |
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| Authors: | Li-xin Yu Zhi-peng Wang Shao-jie Fu Yi-bin Wang Chu-fu Du Jian Xu Wen-feng Deng |
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| Affiliation: | Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. liuxy@fimmu.com |
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| Abstract: | OBJECTIVE: To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplantation. METHODS: The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection. RESULTS: HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality. CONCLUSIONS: HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation. |
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