Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation |
| |
作者姓名: | LiuQ ChenT ChenH ZhangM LiN LuZ MaP CaoX |
| |
作者单位: | InstituteofImmunology,SecondMilitaryMedicalUniversity,Shanghai200433China) |
| |
摘 要: | Dendritic cells (DCs) are the most potent antigen-presenting cells that play crucial roles in the regulation of immune response, friptolide, an active component purified from the medicinal plant Tripterygium wilfordii Hook F. has been demonstrated to act as a potent immunosuppressive drug capable of inhibiting T cell activation and proliferation. However. little is known about the effects of triptolide on DCs.
|
关 键 词: | PG-490 树状细胞 p38 免疫细胞 免疫抑制药 细胞激化 |
本文献已被 维普 等数据库收录! |