牙周炎症时基质金属蛋白酶-9的表达与胎膜早破的关系

目的分析牙周状况与胎膜早破的关系,为孕前及孕期妇女口腔疾病防治提供依据。方法选择18例早产胎膜早破孕妇设为PPROM组,20例足月胎膜早破孕妇设为PROM组,28例足月正常孕妇作为对照组,检查并记录3组的菌斑指数（PLI）、探诊深度（PD）和龈沟出血指数（SBI）,并采用免疫组织化学法检测宫颈部胎膜基质金属蛋白酶-9（MMP-9）的分布与表达,分析MMP-9与牙周状况的关系。结果PPROM组和PROM组胎膜MMP-9的表达强度均高于对照组,且差异有统计学意义。绒毛膜中MMP-9表达与PD没有相关性（r=0.053,P=0.075）,与SBI呈正相关（r=0.433,P<0.05）,与PLI呈正相关（r=0.310,P<0.05）。羊膜中MMP-9表达与PD没有相关性（r=0.077,P=0.597）,与SBI呈正相关（r=0.430,P<0.05）,与PLI呈正相关（r=0.324,P<0.05）。结论MMP-9参与了胎膜早破及牙周炎症的病理过程。

Study on the relationship between the expression of matrix metalloproteinase-9 and premature rupture of membrane as pregnant women with periodontal inflammation

Objective To analyze the relationship between periodontal condition and premature rupture of membrane（PROM） in order to provide basis to keep pregnant women from oral diseases. Methods 18 cases of preterm pregnant women with PROM（Group PPROM）and 20 cases of full term pregnant women with PROM（Group PROM）were selected as the study group, and 28 cases of full term normal pregnant women were selected as the control group. Everyone’s plaque index（PLI）, probing depth（PD） and sulcular bleeding index（SBI） were checked and recorded. Meanwhile, immunohistochemical method was used to detect the distribution and expression of matrix metalloproteinase-9 （MMP -9） in fetal membrane of cervix. The relationship between the expression of MMP -9 and PROM was analyzed. Results The expression of MMP-9 in the pregnant women with PROM（Group PPROM and Group PROM） was higher than that in the control group. There was no relationship between the expression of MMP-9 in chorion and PD（r=0.053, P=0.075）. The expression of MMP-9 in chorion had direct correlation with SBI（r=0.433, P<0.05） and PLI （r=0.310, P<0.05）. The expression of MMP-9 in amniotic membrane hadn’t dependence with PD（r=0.077, P=0.597）, while had direct correlation with SBI（r=0.430, P<0.05） and PLI（r=0.324, P<0.05）. Conclusion MMP-9 was involved in the pathological process of PROM and periodontal inflammation.