正常胰腺MSCT灌注成像与个体因素的相关性研究

目的:应用MSCT灌注成像技术,探讨正常胰腺CT灌注参数与年龄及体质指数(BMI)的相关性。方法:对符合正常胰腺纳入标准的35例患者按年龄及BMI分组,分别行16层螺旋CT胰腺灌注成像,三点测量各组胰腺的组织血流量(BF)、血容量(BV)、毛细血管表面通透性(PS)和对比剂平均通过时间(MTT)值,取各组灌注参数平均值,按组别进行统计学分析。结果:①年龄组:44岁(包括44岁)以下组,胰腺BF、BV、PS及MTT灌注值分别为(172.92±77.63)ml/(100g.min)、(61.63±24.37)ml/100g、(175.08±150.44)ml/(100g.min)、(34.74±13.74)s;45～59岁组,其灌注值分别为(181.61±133.36)ml/(100g.min)、(52.30±24.19)ml/100g、(213.44±151.20)ml/(100g.min)、(39.70±15.35)s;60岁(包括60岁)以上组,其灌注值分别为(118.99±37.89)ml/(100g.min)、(45.62±9.40)ml/100g、(202.72±91.08)ml/(100g.min)、(32.17±9.00)s。②BMI组:体质指数为22以下(包括22)组,胰腺BF、BV、PS及MTT灌注值分别为(154.39±79.88)ml/(100g.min)、(52.92±23.79)ml/100g、(209.85±147.52)ml/(100g.min)、(36.51±13.01)s;体质指数为22以上组,其灌注值分别为(182.82±120.96)ml/(100g.min)、(59.66±18.72)ml/100g、(157.68±107.50)ml/(100g.min)、(33.96±14.52)s。相关性分析结果显示,年龄与BF间呈负相关(P<0.05),余胰腺各灌注参数值与年龄及BMI均无相关性(P>0.05)。结论:胰腺的血流灌注,除血流量随年龄增长有逐步下降趋势外,其余受个体因素的影响小。

Correlation study on multislice spiral CT perfusion imaging of normal pancreas and individual factors

Objectives：Using multi-slice CT（MSCT） to explore the relationship between CT perfusion parameters of normal pancreas and the age,body mass index（BMI）.Methods：35 cases with normal pancreas were grouped according to age and BMI,16-slice spiral CT perfusion imaging of pancreas were performed.Three-point measurement approach was used to obtain the values of blood flow（BF）,blood volume（BV）,permeability surface（PS） and mean transit time（MTT） of pancreatic tissues in different groups,respectively.The mean value of each group was regarded as the final value of perfusion parameter,which was then statistically analyzed.Results：①Groups of age：the pancreatic perfusion values of BF,BV,PS and MTT in the Group aged 44 or below were（172.92±77.63）ml/（100g·min）,（61.63±24.37）ml/100g,（175.08±150.44）ml/（100g·min） and（347.35±137.41） 0.1s,respectively;the pancreatic perfusion values of BF,BV,PS and MTT in the Group aged between 45 and 59 were（181.61±133.36）ml/（100g·min）,（52.30±24.19）ml/100g,（213.44±151.20）ml/（100g·min） and（397.00±153.50） 0.1s,respectively;the pancreatic perfusion values of BF,BV,PS and MTT in the Group aging 60 or above were（118.99±37.89）ml/（100g·min）,（45.62±9.40）ml/100g,（202.72±91.08）ml/（100g·min） and（321.65±90.02） 0.1s,respectlvely.②Groups of BMI：The pancreatic perfusion values of BF,BV,PS and MTT in the Group with BMI 22 or below were（154.39±79.88）ml/（100g·min）,（52.92±23.79）ml/100g,（209.85±147.52）ml/（100g·min） and（365.09±130.06） 0.1s,respectively;the pancreatic perfusion values of BF,BV,PS and MTT in the Group with BMI above 22 were（182.82±120.96）ml/（100g·min）,（59.66±18.72）ml/100g,（157.68±107.50）ml/（100g·min） and（339.62±145.17） 0.1s,respectively.It was found by the correlation analysis that negative correlation existed between age and blood flow（P0.05）.And there was no statistical significance existed among groups of age or between groups of BMI（P0.05）.Conclusion：The perfusion parameters of pancreas have not been influenced by individual factors except that the amount of blood flow declined gradually following the increase of age.