| 注射用头孢匹胺与注射用氯诺昔康配伍的稳定性研究 |
| |
| 引用本文： | 方宝霞,陈富超,朱军,李鹏,林洁,杨盼鑫. 注射用头孢匹胺与注射用氯诺昔康配伍的稳定性研究[J]. 安徽医药, 2012, 16(2): 160-162 |
| |
| 作者姓名： | 方宝霞 陈富超 朱军 李鹏 林洁 杨盼鑫 |
| |
| 作者单位： | 湖北医药学院附属东风医院药学部,湖北,十堰,442008;湖北医药学院药学院,湖北,十堰,442000 |
| |
| 基金项目： | 十堰市科学技术研究与开发计划项目 |
| |
| 摘 要： | 目的考察注射用头孢匹胺与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法在[(25±1)℃]下,观察和检测两药配伍液在8 h内的外观及pH值变化,并用高效液相色谱法(HPLC)测定配伍液中头孢匹胺与氯诺昔康的含量变化。结果 8 h内配伍液外观、pH值及氯诺昔康的含量无明显变化,头孢匹胺含量不断下降,8 h含量为96.5%。结论室温条件下,注射用头孢匹胺与注射用氯诺昔康在0.9%氯化钠注射液中8 h内保持稳定。
|
| 关 键 词： | 头孢匹胺 氯诺昔康 配伍 稳定性 HPLC |
Stability and compatibility of cefpiramide and lornoxicam in 0.9% sodium chloride injection |
| |
| Affiliation: | FANG Bao-xia,CHEN Fu-chao,ZHU Jun,et al(Department of Pharmacy,Dongfeng Hospital Affiliated to Hubei University of Medicine,Shiyan,Hubei 442008,China) |
| |
| Abstract: | Objective To evaluate the stability and compatibility of cefpiramide for injection with lornoxicam in 0.9%sodium chloride injection.Methods At room temperature[（25±1）℃],the changes in contents of cefpiramide and lornoxicam were determined simultaneously by HPLC,and the changes in appearance,pH value were observed within 8 hours.Results No significant differences were found in appearance,pH value and the content of lornoxicam for the mixed solution within 8 hours.The content of cefpiramide evidenly decreased over 8 hours,with 96.5% of the initial concentration.Conclusion The mixture of cefpiramide for injection with lornoxicam in 0.9%sodium chloride injection at ambient temperature is stable within 8 hours. |
| |
| Keywords: | cefpiramide lornoxicam compatibility stability HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
