肺表面活性物质联合鼻塞持续正压通气治疗新生儿呼吸窘迫综合征临床观察

目的:探讨应用肺表面活性物质(固尔苏)联合鼻塞持续正压通气(CPAP)治疗新生儿呼吸窘迫综合征的临床疗效.方法:随机选取2009年1月～2011年6月我科新生儿病房入院确诊为新生儿呼吸窘迫综合征的患儿36例,使用肺表面活性物质联合CPAP治疗,观察治疗前后患儿临床症状及血气分析、呼吸机参数的变化及并发症情况.结果:用药后临床症状明显减轻,PO2 、PCO2 、pH、FiO2、PEEP均较用药前明显改善,差异有统计学意义(P＜0.01).结论:肺表面活性物质联合CPAP治疗新生儿呼吸窘迫综合征疗效显著,便于开展.

Clinical Study of Therapy for Neonatal Respiratory Distress Syndrome with Pulmonary Surfactant and CPAP

Objective: To study the clinical effect of pulmonary surfactant(Curosurf) and CPAP on neonatal respiratory distress syndrome.Methods: Randomly 36 cases of newborn infants admitted into Yueyang Women and Children’s Hospital from January 2009 to June 2011 with a confirmed diagnosis of neonatal respiratory distress syndrome were analyzed,who were treated with pulmonary surfactant and continuous positive airway pressure(CACP),and then the clinical syndrome and blood gas analysis of these infants,the readings of the ventilator as well as the complications were studied.Results: The clinical syndrome of newborn infants were improved evidently or disappeared,and PO2,PCO2 and pH were improved significantly(P<0.01).Conclusions: The combination of pulmonary surfactant and CPAP could significantly improve the neonatal respiratory distress syndrome within the primary treatment.