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| 异丙酚对兔缺血-再灌注损伤肝脏能量代谢的影响 | |
| 引用本文： | 林丽娜,徐红,王万铁,陈锡文,李东,方周溪.异丙酚对兔缺血-再灌注损伤肝脏能量代谢的影响[J].温州医学院学报,2006,36(5):419-421. |
| 作者姓名： | 林丽娜 徐红 王万铁 陈锡文 李东 方周溪 |
| 作者单位： | 1. 温州医学院,第一附属医院,麻醉科,浙江,温州,325000 2. 温州医学院,基础医学院病理生理学教研室,浙江,温州,325000 3. 温州医学院,动物实验中心,浙江,温州,325000 4. 温州医学院,检验医学院分析中心,浙江,温州,325000 5. 温州医学院,电镜室,浙江,温州,325000 |
| 基金项目： | 浙江省卫生厅资助项目，温州医学院校科研和教改项目 |
| 摘 要： | 目的:探讨异丙酚对免缺血-再灌注损伤肝脏能量代谢的影响.方法:实验兔30只,随机分为正常对照组(A组)、肝缺血再灌注组(B组)和肝缺血再灌注 异丙酚治疗组(C组),分别观察肝组织内三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、一磷酸腺苷(AMP)含量、总腺苷酸量(TAN)、肝脏的细胞能荷(EC)及肝细胞形态学的变化.结果:C组与B组比较,肝组织内ATP含量及能荷(EC)均明显增高(P＜0.01);与A组比较差异无显著性;C组的肝细胞形态学异常改变较B组显著减轻.结论:异丙酚可通过改善肝细胞的能量代谢而减轻肝缺血再灌注损伤. |
| 关 键 词： | 再灌注损伤 肝脏 能量代谢 异丙酚 |
| 文章编号： | 1000-2138(2006)05-0419-03 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006年1月10日 |
Effect of propofol on hepatocellular energy metabolism in the reperfusion injury after hepatic ischemia in rabbits |
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| LIN Li-na, XU Hong, WANG Wan-tie,et al..Effect of propofol on hepatocellular energy metabolism in the reperfusion injury after hepatic ischemia in rabbits[J].Journal of Wenzhou Medical College,2006,36(5):419-421. | |
| Authors: | LIN Li-na XU Hong WANG Wan-tie |
| Institution: | Department of Anesthesiology, the First Affiliated ttospital of Wenzhou Medical College, Wenzhou 325000 |
| Abstract: | Objective:To study the effect of propofol on hepatocellular energy metabolism in the reperfusion injury after hepatic ischemia in rabbits.Methods: Using hepatic ischemia-reperfusion injury(HIRI) model,30 rabbits were randomly divided into three groups(n=10 in each):control group(A),HIRI group(B) and HIRI propofol group(C).The contents of adenosine triphosphate(ATP),adenosine diphosphate(ADP),adenosine monophosphate(AMP),total adenylic acid number(TAN) were measured,Energy charge(EC) in the liver tissue and hepatocellular morphological changes were observed during HIRI.Results: ATP and E levels in liver tissue in C group were higher than those in B group(P<0.01);and there were no significant differences between C and A group;abnormal morphological changes of liver cells in B group were ameliorated remarkably too during HIRI.Conclusion: Propofol can attenuate HIRI by improving hepatocellular energe metablism. |
| Keywords: | reperfusion injury liver energe metablism propofol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |