| NT—proBNP在老年人慢性心力衰竭评估中的临床意义 |
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| 引用本文： | 黄春,吴文伟,徐春平,杨文彦,董开武,陈晓春.NT—proBNP在老年人慢性心力衰竭评估中的临床意义[J].福建医科大学学报,2009,43(5):389-392. |
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| 作者姓名： | 黄春 吴文伟 徐春平 杨文彦 董开武 陈晓春 |
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| 作者单位： | 福建医科大学,附属协和医院干部病房,福建省老年医学研究所,福州,350001 |
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| 摘 要： | 目的观察≥70岁老年患者心衰不同阶段、心功能分级和左室射血分数（LVEF）对血清氨基末端钠尿肽前体（NT-proBNP）水平的影响。方法入选老年住院患者121例。入院即刻评估慢性心衰所处阶段、NYHA心功能分级，超声心动图评估LVEF，电化学发光免疫法测定血清NT—proBNP水平。结果（1）慢性心衰A，B，C，D各阶段血清NT—proBNP的中位数（Median）分别为61．5，95．0，1102．0和9995．5ng／L。非参数检验显示各组间有显著差异（P=0．000）。各组间年龄、性别构成无显著差别。左室舒张末期内径（LVEDD）／LVEF随着心衰的发展而增大／降低。（2）血清NT—proBNP水平随NYHA心功能分级恶化而增加（P=0．000）。各组间年龄、性别构成无显著差别。（3）LVEF％50％组血清NT—proBNP水平显著高于LVEF≥50％组（P＝0．000）。结论≥70岁老年患者血清NT—proBNP水平与传统的心衰临床评估手段呈现一致的变化，较准确反映慢性心衰的发展进程并随着心衰症状的加重而增加。
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| 关 键 词： | 利钠肽 脑 心力衰竭 充血性 慢性病 |
Clinical Value of NT-proBNP in Diagnosis of Chronic Heart Failure in Elderly Patients |
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| HUANG Chun,WU Wenwei,XU Chunping,YANG Wenyan,DONG Kaiwu,CHEN Xiaochun.Clinical Value of NT-proBNP in Diagnosis of Chronic Heart Failure in Elderly Patients[J].Journal of Fujian Medical University,2009,43(5):389-392. |
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| Authors: | HUANG Chun WU Wenwei XU Chunping YANG Wenyan DONG Kaiwu CHEN Xiaochun |
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| Institution: | HUANG Chun,WU Wenwei,XU Chunping,YANG Wenyan,DONG Kaiwu,CHEN Xiaochun Fujian Institute of Geriatrics,The Affiliated Union Hospital,Fujian Medical University,Fuzhou,350001,China |
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| Abstract: | Objective To investigate the serum concentration of N-amino terminal pro-brain natriuretic peptide (NT-proBNP) in elderly patients (aged 70 years and older) based on the chronic heart failure (CHF) stages,NYHA function classification,and left ventricular ejection fraction (LVEF).Methods CHF stages and NYHA function classification were determined for 121 patients on admission.LVEF and LVEDD were assessed by echocardiography and NT-proBNP was assayed by Roche Diagnostics.Results (1) The median NT-proBNP level... |
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| Keywords: | natriuretic peptide brain heart failure congestive chronic disease |
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