| 苯甲酸利扎曲普坦口腔速崩片的制备 |
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| 引用本文： | 黄东升,产运霞,耿玉先,辛正洪,宋梦薇. 苯甲酸利扎曲普坦口腔速崩片的制备[J]. 华西药学杂志, 2007, 22(1): 65-67 |
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| 作者姓名： | 黄东升 产运霞 耿玉先 辛正洪 宋梦薇 |
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| 作者单位： | 1. 北京万生药业有限责任公司,北京,101113
2. 北京赛生药业有限公司,北京,100176 |
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| 摘 要： | 目的 制备苯甲酸利扎曲普坦口腔速崩片.方法 选用微晶纤维素(MCC)和低取代羟丙基纤维素(LHPC)作为崩解剂,通过粉末直接压片工艺制备口腔速崩片.考察速崩片的性质.结果 当MCC/LHPC的比例为9:1时,其体外崩解时间在20 s以内,体内崩解时间在30 s以内.结论 所制片剂口感良好,优化的工艺可以工业化生产.
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| 关 键 词： | 苯甲酸利扎曲普坦 口腔速崩片 崩解 微晶纤维素 苯甲酸利扎曲普坦 口腔速崩片 tablet oral fast benzoate 工业化生产 工艺制备 优化 口感 片剂 崩解时间 比例 结果 性质 考察 粉末直接压片 崩解剂 LHPC 低取代羟丙基纤维素 |
| 文章编号： | 1006-0103（2007）01-0065-03 |
| 修稿时间： | 2005-01-01 |
Preparation of Rizatriptan benzoate fast disintegrating oral tablet |
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| HUANG Dong-sheng,CHAN Yun-xia,GENG Yu-xian,XIN Zheng-hong,SONG Meng-wei. Preparation of Rizatriptan benzoate fast disintegrating oral tablet[J]. West China Journal of Pharmaceutical Sciences, 2007, 22(1): 65-67 |
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| Authors: | HUANG Dong-sheng CHAN Yun-xia GENG Yu-xian XIN Zheng-hong SONG Meng-wei |
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| Affiliation: | 1. Beijing Win -sunny Pharmaceutical Co. ,Ltd, Belting 101113, China; 2. Beijing Saisheng Pharmaceutical Co. ,Ltd, Beijing 100176, China |
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| Abstract: | OBJECTIVE To prepare a Rizatriptan benzoate fast disintegrating oral tablet.METHODS Microcrystalline cellulose and low substituted hydroxypropylcellulose were used as disintegrants,fast disintegrating tablets could be prepared by direct powder compression method.The properties of these tablets,such as hardness,and disintegration time were investigated to elucidate the disintegration characteristics of these tablets.RESULTS When the MCC/LHPC ratio was 9:1,the disintegration time was within 20 s in vitro test and was within 30 s in mouth,respectively.CONCLUSIONS The selected formulation and preparation technique are good and can contribute to the development of the product. |
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| Keywords: | Rizatriptan benzoate Fast disintegrating oral tablet Disintegration time Microcrystalline cellulose |
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