导滞排石汤对气滞血瘀和湿热下注型肾结石患者尿液代谢的影响

目的:研究导滞排石方对气滞血瘀+湿热下注型肾结石患者尿液代谢的影响,并探讨其机制。方法:180例肾结石伴尿液代谢异常患者随机分为治疗组和对照组。根据患者不同的尿液代谢异常类型给予相应的生活习惯指导和防治建议,治疗组则在此基础上口服导滞排石方,每次200 m L,每日2次。用药7 d为1疗程,共4个疗程。研究结束后采取B超,X片复查结石情况,全自动生化分析仪进行24 h尿生化测定。结果:治疗后治疗组痊愈病例数、总有效率明显高于对照组(P0.05)。治疗组和对照组的尿液代谢异常率均较治疗前降低(P0.05);治疗组的高尿钙症、高草酸尿症、高磷尿症、低尿量的患病率较对照组明显降低(P0.05);治疗组的结石排净人次较对照组增多(P0.05)。治疗组和对照组的24 h尿钙、尿酸、草酸均较治疗前降低,24 h尿镁、尿量均较治疗前升高(P0.05);治疗组的24 h尿磷较治疗前降低,尿枸橼酸较治疗前升高(P0.05);治疗组24 h尿钙、尿酸、草酸、尿磷均较对照组降低,24 h尿镁、枸橼酸、尿量均较对照组升高(P0.05)。结论:导滞排石方可以促进肾结石排出,并且能够通过调整单纯性肾阳性结石患者的尿液代谢,防止病情发展。

Effect of Daozhi Paishi Decoction on Urine Metabolism in Patients with Qi Stagnation, Blood Stasis and Damp-heat Pouring Down Type Kidney Stone

Objective: To observe the effects of Daozhi Paishi decoction on the urine metabolism in patients with Qi stagnation, blood stasis and damp-heat pouring down type kidney stone. Method: The 180 patients with kidney stone accompanied with abnormal urine metabolism were randomly divided into treatment group and control group. According to the different types of abnormal urine metabolism, all the patients received corresponding life guidance and prevention and treatment suggestions. In treatment group, patients also received Daozhi Paishi decoction, 200 mL/time, bid, with 7 days as one treatment course, for a total of 4 courses. After that, the kidney stones were detected with B-ultrasound and X-ray, and the 24-hour urine biochemical detection was done with auto-biochemical analyzer. Result: After treatment, the number of cured cases and total effective rate in treatment group were higher than those in control group (P<0.05). The abnormal rate of urinemetabolism in both groups were was decreased after treatment (P<0.05). The rates of hypercalciuria, hyperoxaluria, high phosphorus urine and low urine output in treatment group were significantly lower than those in control group (P<0.05). The stone elimination rates in treatment group were higher than those in control group (P<0.05). The levels of 24 h urinary calcium, uric acid and oxalic acid in both groups were decreased after treatment (P<0.05), while the levels of 24 h urinary magnesium and urine volume in both groups were increased after treatment (P<0.05). The level of 24 h urinary phosphorus in treatment group was decreased while the level of 24 h urinary citrate in treatment group was increased after treatment (P<0.05). The levels of 24 h urinary calcium, uric acid, oxalic acid, and urinary phosphorus in treatment group were lower than those in control group (P<0.05), while the levels of 24 h urinary magnesium, citrate, and urine volume in treatment group were higher than those in control group (P<0.05). Conclusion: Daozhi Paishi decoction could accelerate the elimination of kidney stones and effectively intervene the urine metabolism of the kidney radiopaque calculus formers to prevent the development of the disease.