幽门螺杆菌与胆汁反流性胃炎的关系研究

目的 观察幽门螺杆菌（Hp）在胆汁反流性胃炎中的感染率以及根除幽门螺杆菌在胆汁反流性胃炎合并幽门螺杆菌感染患者的临床意义。方法 选取2013年10月～2015年10月胃镜下诊断胆汁反流性胃炎的患者248例，同期随机选取慢性浅表性胃炎患者200例作为对照，两组患者均进行Hp检测，观察两组Hp的感染率。将合并Hp感染的胆汁反流性胃炎患者再随机分为实验组与对照组，实验组增加正规抗Hp治疗10天，而对照组仅给予常规治疗。1个月后观察两组临床症状缓解情况及胃镜下炎症修复情况。结果 胆汁反流性胃炎组Hp阳性率为26.21%（65/248例），慢性浅表性胃炎组Hp阳性率为48.00%（96/200例），两组差异有统计学意义（P<0.01）。合并Hp感染的胆汁反流性胃炎患者根除Hp后治疗有效率94.44%，而未根除Hp的治疗有效率75.00%，两组差异有统计学意义（P<0.05）。结论 胆汁反流性胃炎患者的Hp感染率明显低于慢性浅表性胃炎患者。对于合并Hp感染的胆汁反流性胃炎患者，根除Hp能明显提高治疗有效率。

Study of the Relationship between Bile Reflux Gastritis and Helicobacter Pylori infection

Objective To observe the infection rate of helicobacter pylori (Hp) in bile reflux gastritis and the clinical significance of Hp eradication in bile reflux gastritis combined with Hp infection. Methods Hp infection was detected in 248 patients with bile reflux gastritis and 200 patients with chronic gastritis. Hp infection rate was observed between the two groups. The patients with bile reflux gastritis combined with Hp infection were divided into control and experimental groups randomly.The control group was received basic therapy and the experimental group was received Hp eradication therapy for 10 days based on the basic therapy.The clinical symptoms and the gastric mucosa inflammation were observed under gastroscope between the two groups after one month. Results The Hp infection rate in bile reflux gastritis was 26.21%(65/248) while that was 48.00%(96/200)in chronic gastritis group. There was significant difference between the two groups (P<0.01).The overall effective rate was 94.44% in experimental group while that was 75.00% in control group with significant difference between the two groups(P<0.05). Conclusion The Hp infection rate in bile reflux gastritis is much lower than that of in chronic gastritis. The therapeutic effect of bile reflux gastritis combined with Hp eradiation is more significant than that of no Hp eradication.