SP-D在AECOPD中的临床意义及与PCT、CRP的相关性研究

目的 观察到肺表面活性物质蛋白(SP-D)在急性期慢性阻塞性肺病(AECOPD)中的临床意义,分析SP-D与患者肺功能和降钙素原(PCT)、C-反应蛋白(CRP)的相关性。方法以2014年3月~2015年3月在我院接受治疗的90例慢性阻塞性肺疾病(COPD)患者为观察对象,其中稳定期和急性期患者各45例,同时选取45例健康成年人作为对照组。观察三组研究对象SP-D、PCT和CRP水平以及肺功能指标的差异；分析SP-D、PCT和CRP与肺功能以及SP-D与PCT和CRP的相关性。结果三组研究对象的SP-D、PCT、CRP水平存在显著差异,且AECOPD组患者高于稳定期COPD患者,稳定期COPD患者高于对照组(P<0.05)；三组研究对象的肺功能指标存在显著差异,6分钟步行距离(6MWT)、肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC、呼气中断流速(MMEF)和最高呼气流速(PEF)水平由高到低依次为对照组、稳定期COPD组和AECOPD(P<0.05)；SP-D与肺功能相关指标水平呈显著负相关,而PCT水平和CRP水平与肺功能无明显相关关系；SP-D水平与PCT水平显著正相关,而与CRP水平无明显相关关系。结论AECOPD患者血清SP-D水平较高,且SP-D水平与患者的肺功能和血清PCT水平密切相关。

The Clinical Significance of SP-D in AECOPD and itsCorrelation with PCT and CRP

Objective To observe the clinical significance of SP-D in AECOPD,and analyze the correlation between SP-D and pulmonary function in patients with PCT and CRP.Method90 cases of COPD patients treated in our hospital from March 2014 to March 2015 were selected as the object,with 45 cases of stable patients and 45 cases of acute stage patients.At the same time,45 cases of healthy adults were selected as the control group.Observe the level of SP-D,PCT,CRP and lung function indexes in the three groups;the correlation between SP-D,PCT,CRP and pulmonary function,the correlation between SP-D,PCT and CRP were analyzed.ResultsThe level of SP-D,PCT and CRP of three groups had significant differences,and AECOPD patients were higher than patients with stable COPD,patients with stable COPD were higher than that in the control group (P<0.05).Lung function index of the three groups had significant differences,the level of 6MWT,FVC,FEV1,FEV1 / FVC,MMEF and PEF from high to low were control group,stable COPD patients,and AECOPD group(P<0.05).SP-D was negatively correlated with lung function index level,PCT level and CRP level have no significant correlation with lung function.The level of SP-D was significantly positively correlated with the level of PCT,but had no significant correlation with CRP level.ConclusionThe level of SP-D in patients with high AECOPD were higher,and the SP-D level is closely related with the patients'' lung function and level of PCT.