Clonal T-cell Lymphoproliferation Containing Epstein-Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection |
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| Authors: | Shigehiko Ishihara Akio Tawa Keiko Yumura-Yagi Mitsunori Murata Jun-ichi Hara Hyakuji Yabuuchi Kanji Hirai Keisei Kawa-Ha |
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| Affiliation: | Department of Pediatrics, Osaka University Hospital, Fukushima 1-1-50, Fukushima-ku, Osaka 553;Department of Molecular Biology, Tokai University School of Medicine, Isehara 259-11 |
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| Abstract: | A 10-year-old boy with chronic active Epstein-Barr virus (EBV) infection developed T-cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3±, CD4± and HLA-DR±. The genomic DNAs from these cells demonstrated two rearranged T-cell receptor μ-chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T-cell lymphoproliferation. |
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| Keywords: | Epstein-Barr virus Chronic EB virus infection Clonal lymphoproliferation T lymphocyte |
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