Lipid accumulation product (LAP) is related to androgenicity and cardiovascular risk factors in postmenopausal women |
| |
Authors: | Maturana Maria Augusta Moreira Roberta M C Spritzer Poli Mara |
| |
Institution: | aGynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil;bNational Institute of Hormones and Women's Health, CNPq, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil;cLaboratory of Molecular Endocrinology, Department of Physiology, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite, 500/sala 9, Porto Alegre 90050-170, RS, Brazil |
| |
Abstract: | ObjectivesTo investigate whether lipid accumulation product (LAP) is related to androgen and sex hormone binding globulin (SHBG) levels and to cardiovascular risk factors in postmenopausal women with no evidence of established cardiovascular disease.Study designCross-sectional study.Main outcome measuresLAP (waist-58 × triglycerides nmol/L]), LAP ≥ arbitrary cutoff point of 34.5, serum testosterone, SHBG, ultrasensitive C-reactive protein (us-CRP).ResultsForty-nine women (mean age 55 ± 5 years; median amenorrhea time 5.5 years 3–8]) were studied: 14% had the metabolic syndrome and 24.5% were hypertensive. Compared with LAP < 34.5, LAP ≥ 34.5 (n = 29, 59%) was associated with higher testosterone (p = 0.021) and free androgen index (FAI) (p = 0.003) and lower SHBG levels (p = 0.013). Us-CRP (p = 0.012), total cholesterol (p = 0.041), glucose (p = 0.020) and homeostasis model assessment (HOMA) (p = 0.019) were higher, and high-density lipoprotein cholesterol (HDL-C) (p = 0.001) was lower with LAP ≥ 34.5. LAP was positively correlated with total testosterone (r = 0.349, p = 0.014), FAI (rs = 0.470, p = 0.001), us-CRP (r = 0.315, p = 0.042), systolic (r = 0.318, p = 0.028) and diastolic (r = 0.327, p = 0.023) blood pressure, total cholesterol (r = 0.498, p < 0.001) and glucose (rs = 0.319, p = 0.026). LAP was negatively correlated with SHBG (rs = −0.430, p = 0.003) and HDL-C (r = −0.319, p = 0.026).ConclusionsLAP index seems to be associated with androgens and SHBG and with cardiovascular risk factors in postmenopausal women. Also, LAP seems to be a suitable method to screen for cardiovascular risk in postmenopause. |
| |
Keywords: | Abbreviations: BMI body mass index CVD cardiovascular disease DBP diastolic blood pressure ECLIA electrochemiluminescence immunoassay FAI free androgen index HDL-C high-density lipoprotein cholesterol HOMA homeostasis model assessment LDL-C low-density lipoprotein cholesterol NO nitric oxide PCOS polycystic ovary syndrome SBP systolic blood pressure SHBG sex hormone binding globulin TT total testosterone us-CRP ultrasensitive C-reactive protein |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|