不同剂量尿激酶治疗急性心肌梗死的临床研究

目的：探讨不同剂量尿激酶（UK）静脉滴注对急性心肌梗死（AMI）患者的疗效和出血并发症发生情况。方法：将96例AMI患者随机分为观察组（小剂量溶栓组）和对照组（大剂量溶栓组）,各48例。观察组以UK60万U、对照组以UK150万U溶于5%葡萄糖溶液100ml中,30min内静滴完,其他基础治疗两组相同。结果：两组血管再通率、再梗死率、严重并发症发生率、死亡率比较均无显著性差异（P〉0.05）,但观察组出血发生率显著低于对照组（P〈0.01）。结论：以小剂量UK60万U静滴治疗AMI安全、可靠。

Clinical study on different doses of urokinase in patients with acute myocardial infarction

Objective：To investigate the effects and adverse bleeding actions of different doses with intravenous urokinase in acute myocardial infarction（AMI）.Methods：96 cases of AMI patients were randomly divided into two groups,48 cases in each group.The observation group was treated with intravenous urokinase 6×105 U in 100 ml of 5% glucose in 30 minutes and the control group with intravenous urokinase 1.5×106 U.Other treatment in patients of the two groups was correspondence.Results：The rate of reperfusion,reinfarction,severe complications and mortality had no statistical significance between the two groups（P0.05）.But the bleeding rate of the observation group was lower than that of the control group（P0.01）.Conclusion：AMI patients treated with intravenous urokinase 6×105 U is safe.