Ferumoxides and Tc-99m sulfur colloid: Comparison of the tumor-to-liver uptake in focal nodular hyperplasia |
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Authors: | C cile B. Grandin,Bernard E. Van Beers,Stanislas Pauwels,Roger Demeure,Jacques Jamart,Jacques Pringot |
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Affiliation: | Cécile B. Grandin,Bernard E. Van Beers,Stanislas Pauwels,Roger Demeure,Jacques Jamart,Jacques Pringot |
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Abstract: | The tumor-to-liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium-99m (Tc-99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides-enhanced MR imaging and planar Tc-99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor-to-liver ferumoxides uptake was calculated and the Tc-99m sulfur colloid uptake was assessed visually. Ferumoxides uptake was observed in all but one patient with FNH (mean tumor-to-liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc-99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc-99m sulfur colloid uptake in FNH. |
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Keywords: | Magnetic resonance (MR) contrast enhancement Liver, neoplasms Liver, focal nodular hyperplasia Iron, diagnostic use Technetium-99m sulfur colloid Liver, radionuclide study |
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