便携式输注泵输注不同剂型5-氟尿嘧啶临床应用时间差异分析

目的:探讨便携式输注泵输注不同剂型5-氟尿嘧啶的临床应用时间差异原因,规范临床用药.方法:在实验室理想条件下,分过滤和不过滤2种情况,测定氟尿嘧啶注射液、氟尿嘧啶粉针剂在便携式输注泵中的输液时间及渗透压、pH值、澄清度、含量等可能影响流速的药学性能因素.结果:与氟尿嘧啶注射液相比,使用便携式输注泵持续输注不同氟尿嘧啶粉...

Analysis of clinical using time difference of different dosage forms of fluorouracil injection with portable infusion pump

Objective: To explore the difference of clinical using time of fluorouracil powder and injection in portable infusion pump, and analyze the reasons, so as to guide clinical medication. Methods: Under ideal laboratory conditions and filtering or no filtering, the infusion time, osmotic pressure, pH value, clarity and content of fluorouracil injection and fluorouracil powder in portable infusion pump were determined, which may affect the flow rate of pharmaceutical properties. Results: Compared with the continuous infusion of different fluorouracil powder injection and fluorouracil injection using portable infusion pump, fluorouracil powder injection has prolonged the infusion time. And different brand powder injection also has bigger difference, such as fluorouracil A 57 h, fluorouracil B 90 h, this is consistent with clinical use. Before the liquid was filtered, the clinical infusion speed of the two kinds of fluorouracil powder was significantly different. However, after filtration, the infusion speed of the two kinds of fluorouracil powder was basically the same as that of fluorouracil injection, and there was no significant difference in drug concentration, osmotic pressure, and pH value. Combined with the clarity test results of the drug solution, the main factor affecting the infusion time of fluorouracil powder injection in the portable infusion pump is the presence of non-drug active excipients in the preparation. Conclusions: The infusion speed of fluorouracil powder and injection in the clinical use of portable infusion pump is significantly different. The main reason for the difference in the clinical use of fluorouracil powder from different manufacturers is the difference in preparation and excipients, which suggests that attention should be paid to clinical use.