Measurement of collateral blood flow in a porcine model of aortic coarctation by velocity-encoded cine MRI

The purpose of this study was to investigate the time course of development of collateral blood flow in an animal model of aortic coarctation. A juxtaductal aortic stenosis (model coarctation) was surgically created in five juvenile pigs. MRI was performed preoperatively, 1 to 2 days postoperatively, and 2 to 10 weeks postoperatively. Aortic blood flow was measured by velocity-encoded cine MR (VENC-MR). The percent change in aortic blood flow (ΔBF) from proximal to distal descending thoracic aorta was calculated, and a multiple-comparison paired t test used to assess changes in ΔBF over time. Invasive flow measurements were obtained in one animal before sacrifice using an ultrasonic probe. ΔBF preoperatively was ?2 ± 8% (mean ± SE). ΔBF increased to 32 ± 7% (mean ± SE, P = .022) 2 days postoperatively and 55 ± 19% (P = .032) 2 to 8 weeks postoperatively. Invasive measurements were in qualitative agreement with the VENC-MR data. VENC-MR is an accurate noninvasive method of measuring collateral blood flow in aortic coarctation. Recruitment and development of collateral flow pathways occur rapidly in an animal model.