Synthesis of Vinca Alkaloids and Related Compounds. Part 84. Sulfonamide Derivatives of Some Vinca Alkaloids with Cardiovascular Activity |
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Authors: | Istv n Moldvai,Eszter Temesv ri-Major,Csaba Sz ntay,G bor T th,Egon K rp ti,Csaba Sz ntay |
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Affiliation: | István Moldvai,Eszter Temesvári-Major,Csaba Szántay,Gábor Tóth,Egon Kárpáti,Csaba Szántay |
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Abstract: | (+)?Vincamine ( 1 ) and (+)?vinpocetine ( 2 ) were chlorosulfonylated and the resulting sulfonyl chloride isomers ( 3–6 ) were transformed into sulfonamides ( 7–10 ). The ester group of sulfonamides was modified by selective hydrolysis and transesterification. Apovincaminol derivatives ( 14–16 ) were also prepared by reduction. In addition to the known cerebrovascular effects of the unsubstituted compounds ( 1,2 ), sulfonamides also show a significant peripheral vasodilator effect. |
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Keywords: | Eburnanes alkaloids sulfonamide cardiovascular activity antihypoxic activity |
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