| The Ultracytochemical Effects of High Energy Shock Wave on Rabbit Liver |
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| 作者姓名： | 张东生 金立强 洪大蓉 |
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| 作者单位： | Zhang Dongsheng Jin Liqiang Hong Darong Laboratory of Electron Microscopy，Nanjing Railway Medical College Nanjing\ 210009，P.R.China |
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| 摘 要： | ＴｈｅＵｌｔｒａｃｙｔｏｃｈｅｍｉｃａｌＥｆｆｅｃｔｓｏｆＨｉｇｈＥｎｅｒｇｙＳｈｏｃｋＷａｖｅｏｎＲａｂｂｉｔＬｉｖｅｒＺｈａｎｇＤｏｎｇｓｈｅｎｇ（张东生）①ＪｉｎＬｉｑｉａｎｇ（金立强）ＨｏｎｇＤａｒｏｎｇ（洪大蓉）ＬａｂｏｒａｔｏｒｙｏｆＥｌ...
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The Ultracytochemical Effects of High Energy Shock Wave on Rabbit Liver |
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| Zhang Dongsheng Jin Liqiang Hong Darong Laboratory of Electron Microscopy,Nanjing Railway Medical College Nanjing\ ,P.R.China.The Ultracytochemical Effects of High Energy Shock Wave on Rabbit Liver[J].Journal of Nanjing Medical University,1997(1). |
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| Authors: | Zhang Dongsheng Jin Liqiang Hong Darong Laboratory of Electron Microscopy Nanjing Railway Medical College Nanjing\ PRChina |
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| Institution: | Zhang Dongsheng Jin Liqiang Hong Darong Laboratory of Electron Microscopy,Nanjing Railway Medical College Nanjing\ 210009,P.R.China |
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| Abstract: | The ultracytochemical effects in the liver of rabbit undergoing high energy shock wave (HESW) were studied with electron microscope. The application of lanthanum as a tracer for ultrastructural study demonstrated that intracellular lanthanum could be observed, most of which entered the hepatocytes and its mitochondria. The lanthanum granules were also found to deposite in the zone of tight junctions of bile canaliculi, which indicated that the tight junctions had been damaged. The activities of succinate dehydrogenase (SDH) in liver cells, alkaline phosphatase (ALP) and thiamine pyrophosphatase (TPPase) on the wall of bile canaliculi became diminished obviously. Both the activites and localizations of TPPase had changed. Some TPPase from the damaged lysosome like vesicles and Golgi saccules of liver cells discharged into cytoplasm. TPPase reaction production in some bile canaliculi decreased. In the intercellular space of the liver cells and the tight junctions of bile canaliculi TPPase reaction could be seen. Ultrastructurally, the changes commonly seen were hydropic mitochondria and dilatation of rough endoplasmic reticulum. Serologic test demonstrated that there was an abnormal change of SGPT, SGOT and ALP. The results showed that HESW can damage the ultrastructure and function of liver. |
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| Keywords: | lanthanum nitrate succinate dehydrogenase alkaline phosphatase thiamine pyrophosphatase high energy shock wave ultracytochemistry |
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