| 冰冻储存对HPLC法测定血清中苯妥英钠、卡马西平的影响 |
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| 引用本文： | 郭新社,杨广杰. 冰冻储存对HPLC法测定血清中苯妥英钠、卡马西平的影响[J]. 河南大学学报(医学版), 2004, 23(1): 22-23 |
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| 作者姓名： | 郭新社 杨广杰 |
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| 作者单位： | 河南大学药学院,药物分析教研室,河南,开封,475001;河南大学药学院,药物分析教研室,河南,开封,475001 |
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| 摘 要： | 目的 :本实验考察了不同时间冰冻储存 ($C2 0℃ ) [1] 对血清中苯妥英钠、卡马西平HPLC色谱图和测定结果的影响。方法 :记录经过不同时间冰冻储存的血清的HPLC色谱图、计算血清中苯妥英钠、卡马西平的浓度 ,考察每个血清 5次测定结果之间有无显著性差异。结果 :经过不同时间冰冻储存的血清 ,其HPLC色谱图基本上没有发生变化 ,血清中苯妥英钠、卡马西平浓度 5次测定结果之间无显著性差异。结论 :在冰冻条件下储存血清不影响对苯妥英钠、卡马西平的测定。
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| 关 键 词： | 苯妥英钠 卡马西平 冰冻储存 治疗药物监测 |
| 文章编号： | 1672-7606(2004)01-0022-02 |
| 修稿时间： | 2003-11-08 |
Affection of freezing store on the determination of phenytoin and carbamazepine in human plasma |
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| GUO Xin-she,YANG Guang-jie. Affection of freezing store on the determination of phenytoin and carbamazepine in human plasma[J]. Journal of Henan University, 2004, 23(1): 22-23 |
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| Authors: | GUO Xin-she YANG Guang-jie |
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| Abstract: | Objective: To study the HPLC chromatogram and the concentrations of phenytoin and carbamazepine in human plasma after freezing store (–20℃) for different time. Methods: The HPLC chromatogram was recorded and the concentrations of phenytoin and carbamazepine in human plasma after freezing store for different time were calculated. Whether there was notable difference between the 5 determined concentrations of each plasma was determined. Results: The HPLC chromatogram were almost the same and there were no notable difference between the 5 determined concentrations of phenytoin and carbamazepine in human plasma after freezing store for different time. Conclusion: Freezing store does not affect the determination of phenytoin and carbamazepine in human plasma. |
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| Keywords: | phenytoin carbamazepine clinical monitoring of drugs freezing store (3/20℃) |
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