Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features |
| |
| Authors: | Jürgen Bernhagen Thierry Calandra Richard Bucala |
| |
| Institution: | (1) Laboratory of Biochemistry, Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany, DE;(2) Division of Infectious Diseases, Department of Internal Medicine, Centre Hopitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland, CH;(3) The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA, US |
| |
| Abstract: | The classical T cell cytokine macrophage migration inhibitory factor (MIF) has reemerged recently as a critical mediator
of the host immune and stress response. MIF has been found to be a mediator of several diseases including gram-negative septic
shock and delayed-type hypersensitivity reactions. Its immunological functions include the modulation of the host macrophage
and T and B cell response. In contrast to other known cytokines, MIF production is induced rather than suppressed by glucocorticoids,
and MIF has been found to override the immunosuppressive effects of glucocorticoids. Recently, elucidation of the three-dimensional
structure of MIF revealed that MIF has a novel, unique cytokine structure. Here the biological role of MIF is reviewed in
view of its distinct immunological and structural properties.
Received: 12 May 1997 / Accepted: 20 June 1997 |
| |
| Keywords: | Macrophage migration inhibitory factor Cytokine Glucocorticoids Neuroendocrine Septic shock T cell Monocytes/macrophage Molecular structure |
| 本文献已被 SpringerLink 等数据库收录！ |
|
