| 正交试验法优选止颤汤提取工艺 |
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| 引用本文： | 杨秀娟,洪燕龙,吴飞,阮克锋,冯怡.正交试验法优选止颤汤提取工艺[J].中国实验方剂学杂志,2013,19(9):21-24. |
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| 作者姓名： | 杨秀娟 洪燕龙 吴飞 阮克锋 冯怡 |
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| 作者单位： | 上海中医药大学中药现代制剂技术教育部工程研究中心,上海 201203;上海张江中药现代制剂技术工程研究中心,上海 201203 |
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| 基金项目： | 上海市科委中药现代化专项(10DZ1973000);上海高校选拔培养优秀青年教师科研专项基金(szy09006);上海市自然科学基金项目(09ZR1429600);上海市教委创新项目(10YZ57);上海市教委重点学科项目(J50302) |
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| 摘 要： | 目的:优选复方止颤汤的提取工艺.方法:采用HPLC测定钩藤碱、异钩藤碱、芍药苷含量；以钩藤碱、异钩藤碱、芍药苷提取率为指标,通过L9(34)正交试验考察加水量、提取时间、提取次数对提取工艺的影响.结果:最佳提取工艺条件为加10倍量水提取2次,每次1h.结论:优选的止颤汤提取工艺稳定可行,提取率高.
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| 关 键 词： | 正交试验 提取工艺 止颤汤 钩藤碱 异钩藤碱 芍药苷 |
| 收稿时间： | 2012/9/26 0:00:00 |
Optimization of Extraction Technology for Zhichan Decoction by Orthogonal Test |
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| YANG Xiu-juan,HONG Yan-long,WU Fei,RUAN Ke-feng and FENG Yi.Optimization of Extraction Technology for Zhichan Decoction by Orthogonal Test[J].China Journal of Experimental Traditional Medical Formulae,2013,19(9):21-24. |
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| Authors: | YANG Xiu-juan HONG Yan-long WU Fei RUAN Ke-feng and FENG Yi |
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| Institution: | Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine(TCM), Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine(TCM), Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine(TCM), Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine(TCM), Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine(TCM), Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM, Shanghai 201203, China |
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| Abstract: | Objective: To optimize extraction technology of compound Zhichan decoction. Method: With the content of rhynchophylline,isorhynchophylline,paeoniflorin as index,which were determined by HPLC,effects of the amount of water,extraction time,extraction times on extraction technology was investigated by L9(34) orthogonal test. Result: Optimal extraction technology conditions were as followings:extracted 2 times with 10 folds the amount of water,1 h per time. Conclusion: This optimized extraction technology was stable and feasible with high extraction rate. |
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| Keywords: | orthogonal test extraction process Zhichan decoction rhynchophylline isorhynchophylline paeoniflorin |
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