女性乳腺癌危险因素的病例对照研究

目的探求女性乳腺癌的危险因素,为乳腺癌的防治提供依据。方法采用病例对照研究方法,问卷调查2003年1月~2005年4月入院的经病理组织学确诊的女性乳腺癌生存病例及同时段入院的外伤患者。利用SPSS进行数据录入和分析,用logistic回归模型进行单因素和多因素分析筛选出有意义的危险因素。结果经单因素及多因素分析,与乳腺癌发病有关的因素为:月经经期不规则、行经期长、流产史、青霉素过敏史等,月经初潮晚能降低乳腺癌的发病风险。结论月经经期不规则、行经期长、流产史及青霉素过敏史等是乳腺癌危险因素,而月经初潮晚对乳腺癌有保护作用。

A case-control study on risk factors of female breast cancer

Objective A case control study was conducted to explore risk factors of female breast cancer.Methods Total 500 female survivors with breast cancer were surveyed,matched with trauma controls in hospital at the same time.SPSS 2000 was used to code and enter the data.Univariate and multivariate logistic regression analysis were performed for screening the significant risk factors of breast cancer.Results Univariate and multivariate logistic regression analysis indicated that long paramenstrum,irregularity of menstruation periods,abortion and the allergic reactions to penicillin were all related to the female breast cancer,while late menarche could protect female from breast cancer.Conclusions Long paramenstrum,irregularity of menstruation periods,abortion and the allergic reactions to penicillin were risk factors of female breast cancer,while late menarche was the protective factor.