Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy |
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| Authors: | Mikko Jalanko Mika Tarkiainen Petri Sipola Pertti Jääskeläinen Kirsi Lauerma Mika Laine |
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| Affiliation: | 1. Department of Cardiology, Helsinki University Hospital, Heart and Lung Center, Helsinki, Finland;2. Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland;3. Heart Center, Kuopio University Hospital, Kuopio, Finland;4. HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland |
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| Abstract: | Objective: We assessed the value of speckle tracking two-dimensional (2D) strain echocardiography (2DSE) measured mechanical dispersion (MD) with other imaging and electrocardiographic parameters in differentiating hypertrophic cardiomyopathy (HCM) patients with and without nonsustained ventricular tachycardia (NSVT) on 24-h ambulatory ECG monitoring.Methods and results: We studied 31 patients with HCM caused by the Finnish founder mutation MYBPC3-Q1061X and 20 control subjects with comprehensive 2DSE echocardiography and cardiac magnetic resonance imaging (CMRI). The presence of NSVT was assessed from ambulatory 24-h ECG monitoring.NSVT episodes were recorded in 11 (35%) patients with HCM. MD was significantly higher in HCM patients with NSVT (93?±?41?ms) compared to HCM patients without NSVT (50?±?18?ms, p?=?0.012) and control subjects (41?±?16?ms, p?Conclusions: Increased mechanical dispersion was associated with NSVT in HCM patients on 24-h ambulatory ECG monitoring. - Key messages
The prediction of sudden cardiac death in hypertrophic cardiomyopathy remains a challenge and novel imaging methods are required to identify individuals at risk of malignant ventricular arrhythmias. Mechanical dispersion by speckle tracking echocardiography is associated with NSVT on 24-h ambulatory ECG monitoring in patients with hypertrophic cardiomyopathy
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| Keywords: | Arrhythmia cardiac magnetic resonance echocardiography risk assessment speckle tracking sudden cardiac death |
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