EECP对于改善高血压病伴IGT患者血管内皮功能以及PWV的影响

目的:观察增强型体外反搏(EECP)对于改善高血压病并发糖耐量减低(IGT)患者血管内皮功能以及脉搏波传导速度(PWV)的影响。方法:将80例高血压病伴IGT患者分为EECP组(44例)和对照组(36例)。两组患者均进行常规降血压治疗,EECP组在常规治疗基础上进行EECP治疗。测定两组患者治疗前后血压、肱踝脉搏波传导速度(ba PWV)以及血浆中内皮素(ET)和一氧化氮(NO)的含量,并进行对比分析。结果:两组患者治疗后收缩压和舒张压比治疗前均有显著下降(均P0.01),但是两组间血压下降幅度并无明显差异。EECP组和对照组患者治疗后ba PWV均有显著下降,ET也有显著下降,NO则有显著上升。但是EECP组ba PWV、ET和NO较对照组改善的更为显著(均P0.05)。结论:EECP能有效改善高血压病伴IGT患者血管内皮功能以及PWV。

Influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance

AIM：To explore the effect of enhanced external counterpulsation （EECP） on the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance （IGT）. METHODS： Eighty hypertensive patients complicated by IGT were divided into treatment group （n=44, conventional treatment＋EECP） and control group （n=36, conventional treatment）. Both groups received conventional antihypertensive treatment, but EECP was added in the treatment group based on the conventional treatment. Blood pressure, pulse wave velocity, endothelin （ET） and nitric oxide （NO） were measured and compared between groups. RESULTS： Blood pressure in the two groups after treatment was dramatically reduced （P〈0.01）, but there was no significant difference between groups. The baPWV of patients in treatment group （1602±214） vs.（1890±251） cm/s, P〈0.01] and control group （1704±221） vs.（1893±243） cm/s, P〈0.05] after treatment decreased significantly. The ET level of patients in the treatment group （63±21） vs.（90±24） ng/L, P〈0.01] and control group （75±20） vs.（90±24） ng/L, P〈0.05] also decreased significantly after treatment. However, NO level of patients in treatment group （79±17） vs.（51±19） mmol/L, P〈0.01] and control group （68±17） vs.（51±18） μmol/L, P〈0.05] increased significantly after treatment. However, the baPWV, ET and NO of patients in treatment group improved more significantly compared with those in the control group （P〈0.05）. CONCLUSION： Enhanced external counterpulsation can improve the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance.