| Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices |
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| 引用本文： | Lu - Ying Liu Er - Qing Wei Yan- Min Zhao Fang - Xue Chen Meng - Ling Wang Wei - Ping Zhang Zhong Chen. Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices[J]. 中国药理通讯, 2005, 22(4): 40-40 |
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| 作者姓名： | Lu - Ying Liu Er - Qing Wei Yan- Min Zhao Fang - Xue Chen Meng - Ling Wang Wei - Ping Zhang Zhong Chen |
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| 作者单位： | Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031 |
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| 摘 要： | Baicalin is a flavonoid derivative from Scutellaria baicalensis Georgi with various pharmacological effects. Recently, the neuroprotective effect of baicalin has been reported. To confirm this effect and explore the possible mechanism, we investigated the protective effect of baicalin on ischemic-like or excitotoxic injury and the activation of protein kinase C （ （PKC（） in rat hippocampal slices. In vitro ischemic-like injury was induced by oxygen/glucose deprivation （OGD） and the excitotoxic injury by N - methyl - D - aspartate （NMDA）. The viability and swelling of the slices were detected by TTC staining and image analysis of light transmittance （LT）, respectively,
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| 关 键 词： | 保护作用 缺氧状态 葡萄糖 NMDA 大脑海马 |
Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices |
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| Lu;-;Ying;Liu;Er;-;Qing;Wei;Yan-;Min;Zhao;Fang;-;Xue;Chen;Meng;-;Ling;Wang;Wei;-;Ping;Zhang;Zhong;Chen. Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices[J]. , 2005, 22(4): 40-40 |
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| Authors: | Lu - Ying Liu Er - Qing Wei Yan- Min Zhao Fang - Xue Chen Meng - Ling Wang Wei - Ping Zhang Zhong Chen |
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