| 鲨鱼软骨提取物对小鼠实体瘤抑制作用的实验研究 |
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| 引用本文： | 梁安民,匡志鹏,谢裕安,梁宁生,陆益,杨帆,莫钦国.鲨鱼软骨提取物对小鼠实体瘤抑制作用的实验研究[J].广西医科大学学报,2001,18(1):12-13. |
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| 作者姓名： | 梁安民 匡志鹏 谢裕安 梁宁生 陆益 杨帆 莫钦国 |
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| 作者单位： | 广西肿瘤防治研究所南宁 530021 |
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| 基金项目： | “广西科学研究与技术开发资助项目”资助! (桂科攻 9735 0 2 5 ) |
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| 摘 要： | 目的：观察鲨鱼软骨粉（商品名Shark Cartilade,SC)及其提取物（Shark cartilage extracts,SCE)对荷肝癌（Hep)小鼠和肉瘤S180小鼠的抑瘤作用。方法：将荷肝癌（Hep)小鼠40只随机分为4组：鲨鱼软骨提取物组（SCE）、鲨鱼软骨粉高剂量组（SCH）、鲨鱼软骨粉低剂量组（SCL）和生理盐水对照组（NS）。灌胃给药，每天1次，连用14d，经动物脉瘤重计算抑瘤率。同样方法处理50只荷S180小鼠。结果：SEC、SCH和SCL组对Hep的抑瘤率分别为38．72％、19．78％、16．84％；对S180的抑瘤率分别为45．19％、4．10％和3．79％。结论：鲨鱼软骨制剂对小鼠Hep和小鼠S180实体瘤均有一定的抑制作用，但其提取物SCT的抑瘤率明显高于鲨鱼软骨粉SC（P＜0．01或P＜0．05）。
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| 关 键 词： | 鲨鱼软骨粉 鲨鱼软骨提取物 抑瘤作用 小鼠 |
| 修稿时间： | 2000年11月20 |
AN EXPERIMENTAL STUDY OF SHARK CATILAGE EXTRACTS TUMOR-INHIBITING EFF ECT ON MICE |
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| Liang Anmin,Kuang Zhipeng,Xie Yuan,et al.AN EXPERIMENTAL STUDY OF SHARK CATILAGE EXTRACTS TUMOR-INHIBITING EFF ECT ON MICE[J].Journal of Guangxi Medical University,2001,18(1):12-13. |
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| Authors: | Liang Anmin Kuang Zhipeng Xie Yuan |
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| Abstract: | Objective:To observe the inhibition effect of Shark Cartilade(SC) and Shark cartilage extracts (SCE) on tumor of Hep mice and S180 mice Methods:40 Hep mice were randomized into 4 groups:group of shark cartilage extracts (group NS) All drugs were separatly given infusing intl stomach (ig) at the second dady after inoculation ,once a day,lasted for 14 days,and then all animals were killed and the neopolasm weighed,tumor inhibited rate calculated 50 S180 mice were treated in all the same way Results:The tumor inhibiting rates of group SCE,SCH and SCL were reepectioely 45 19%,4 10%and 3 79% Conclusion:Both SCE and SC can inhibit tumor growth,but SCE has more powerful tumor inhibiting effects than SC (P<0 01 or P<0 05) |
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| Keywords: | shark cartilage extracts(SCE) shark cartilade (SC) tumor inhibited effect |
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