ADULT T CELL LEUKEMIA HISTOLOGICAL CLASSIFICATION AND CHARACTERISTICS |
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| Authors: | Masao Hanaoka,Masamichi Sasaki,,Hidetoshi Matsumoto,,Hidemitsu Tankawa,° ,Hirohiko Yamabe,° ° ,Kazuhiko Tomimoto,° ° ° ,Chikao Tasaka,+,Hisayoshi Fujiwara,+,Takashi Uchiyama,++ Kiyoshi Takatsuki,++ |
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| Affiliation: | *Department of Pathology, Institute for Vim Research, Kyoto University;**Department of Pathology, Osaka Red Cross Hospital, Kyoto University.;***Division of Pathology, Shinko Hospital, Kyoto University.;°Division of Pathology, Amagasaki Hospital, Kyoto University.;°°Division of Pathology, Tenri Hospital, Kyoto University.;°°°Division of Pathology, Kyoto University.;+Second Department of Pathology, Kyoto University.;++First Department of Internal Medicine, School of Medicine, Kyoto University. |
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| Abstract: | Adult T cell leukemia was classified into two distinct types, monomorphic and pleomorphic, according to their histological and cytological features. The former type is composed of uniform neoplastic cells with round or slightly indented nuclei without any marked deformation. The latter type, on the other hand, occupies a unique position in lymphocytic leukemias with the following characteristics: a) onset in adulthood, b) an acute and subacute course, c) well-differentiated T cell origin of the neoplastic cells, d) pleomor-phism of the neoplstic cells with markedly deformed nuclei, e) difkuse proliferation of the neoplastic cells without nodular pattern, f) histologically heterogeneous features of lymph nodes frequently admixing a cluster of normal lymphocytes, proliferation of macrophages and dendritic cells, and well-developed high endothelium venules, g) high incidence of skin lesions due to the infiltration of neoplastic cells, and h) exclusively limited localization of patients' birth places. |
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