| 宁嗽露中盐酸麻黄碱的含量测定 |
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| 引用本文： | 解玲,范秀玉.宁嗽露中盐酸麻黄碱的含量测定[J].齐鲁药事,2011,30(4):213-215. |
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| 作者姓名： | 解玲 范秀玉 |
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| 作者单位： | 1. 山东药品食品职业学院,山东威海,264210
2. 山东绿叶制药有限公司,山东烟台,264004 |
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| 摘 要： | 目的建立高效液相色谱法测定宁嗽露中盐酸麻黄碱的含量。方法采用反相高效液相色谱法,C18色谱柱,流动相为醋酸铵缓冲液-甲醇-乙腈(94:1:5),检测波长为257 nm,流速为1.0 mL.min-1,柱温40℃。结果盐酸麻黄碱浓度在0.058~0.58 mg.mL-1范围内浓度与峰面积呈良好的线性关系(r=0.999 2),该制剂中盐酸麻黄碱的平均回收率为99.12%,RSD为0.92%(n=5)。结论该方法简便、准确、可靠,可用于宁嗽露中盐酸麻黄碱的含量测定。
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| 关 键 词： | 盐酸麻黄碱 高效液相色谱 宁嗽露 |
Determination of ephedrina hydrochloridum in Ningsoulu |
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| JIE Ling,FAN Xiu-yu.Determination of ephedrina hydrochloridum in Ningsoulu[J].qilu pharmaceutical affairs,2011,30(4):213-215. |
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| Authors: | JIE Ling FAN Xiu-yu |
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| Institution: | JIE Ling1,FAN Xiu-yu2 (1.Shandong Drug and Food Vocational College,Weihai 264210,China,2.Shandong Lvye Pharmaceutical Co.,Ltd.,Yantai 264004,China) |
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| Abstract: | Objective To establish an HPLC method to determine ephedrine hydrochloride in Ningsoulu.Methods The assay wavelength was carried out on ODS C18 column with ammonium acetate buffer solution-methanol-acetonitrile（94：1：5） as mobile phase.The detection wavelength was 257 nm.The flow rate was 1.0 mL·min-1 and column temperature was 40 ℃.Results The linear range of ephedrine hydrochloride was 0.058～0.58 mg·mL-1（r=0.999 2）.The average recovery was 99.12% with RSD 0.92%（n=5）.Conclusion This method was convenient,reliable and accurate,it can be used for the determination of ephedrine hydrochloride in Ningsoulu. |
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| Keywords: | Ephedrine hydrochloride HPLC Ningsoulu |
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