成人髓母细胞瘤的诊断和治疗

目的 探讨成人髓母细胞瘤的临床特点、诊断和治疗方法.方法 回顾性分析我院2000 年8月至2008 年12 月期间收治的16 例成人髓母细胞瘤的临床及影像学表现、治疗措施与效果.结果 肿瘤全切除12 例,次全切除3 例,部分切除1 例,术后均行放疗,3 例同时行化疗.术后复发3 例,术后2 年生存率86.7%,5 年生存率66.7%.结论 成人髓母细胞瘤发生于后颅窝中线区者多见.手术切除及术后全脑脊髓放疗是主要治疗方法.复发者预后差.

Diagnosis and treatment of adult medulloblastoma

Objective To explore the clinical characteristics, diagnosis and optimal method of adult medulloblastoma. Methods The clinical characteristics, imaging features, thrapeutic methods and outcomes of 16 adult patients with medulloblastoma who were treated in our department between August, 2000 and December, 2008, were analyzed retrospectively . Results Of 16 patients with medulloblastoma, 12 underwent total resection of the tumors, subtotal 3 and 1 partial. All the patients accepted radiotherapy and 3 received adjuvant chemotherapy postoperatively. Three patients had recurrance after initial treatment. The survival rates in 2 and 5 years were 86.7 % and 66.7 % respectively. Conclusions Midline of the posterior fossa is predominant location of adult medulloblastoma. Microsurgery and postoperative craniospinal radiotherapy are the mainstay treatments for this disease. The prognosis of recurrant patients were very poor.