Genomic epidemiological investigation of a Streptococcus suis outbreak in Guangxi,China, 2016 |
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| Affiliation: | 1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;2. Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, China;3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China;4. Jingxi Center for Diseases Control and Prevention, Jingxi, Guangxi, China;5. Hengxian Center for Diseases Control and Prevention, Hengxian, Guangxi, China;1. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China;2. Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing 210095, China;3. OIE Reference Lab for Swine Streptococcosis, Nanjing 210095, China;4. Experimental Teaching Center of Life Science, Nanjing Agricultural University, Nanjing 210095, China;5. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China;6. Novel Bioinformatics Co., Ltd, Shanghai, China |
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| Abstract: | In June 2016, a Streptococcus suis outbreak occurred in Guangxi, China. We determined the genetic characteristics of six clinically isolated strains by serotyping, PCR, and whole-genome sequencing, performing genome epidemiology analysis on these and 961 public available S. suis genomes. We also classified the first sequence type ST665 human case. Sporadic and outbreak cases were distinguished by whole-genome sequencing and phylogenomics. This approach could help to prevent and control S. suis epidemics in Guangxi and the wider region. |
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