Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis |
| |
| Institution: | 1. Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark;2. Department of Neurology, University Hospital Cologne, Cologne, Germany;3. Department of Psychology and Behavioural Sciences, Department of Oncology, Aarhus University & Aarhus University Hospital, Denmark;4. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark;5. Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark;6. Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK;7. Division of Neuroscience, Newcastle University, Newcastle, UK;1. Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;2. Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;3. School of Natural Sciences, Eskitis Institute for Drug Discovery, Griffith University Nathan, Queensland, Australia;4. Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;5. Dept. of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran |
| |
| Abstract: | BackgroundIncreasingly, evidence from brain imaging supports the role of neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial and temporal susceptibility to neuroinflammatory processes in the brain that may correspond to dementia staging or symptom expression.MethodsWe searched literature databases for case-control studies examining levels of translocator protein (TSPO) levels using positron emission tomography, representing neuroinflammation, in regional analyses between healthy controls and mild cognitive impairment (MCI) or Alzheimer’s disease (AD) subjects. Standardised mean differences (SMDs) were calculated and results meta-analysed using random-effects models. Quality assessments, sensitivity analysis, subgroup analysis and meta-regressions were also performed.ResultsTwenty-eight studies comprising 755 (HC = 318, MCI = 168, AD = 269) participants and 37 brain regions were included. Compared to HCs, AD participants had increased TSPO levels throughout the brain (SMD range: 0.43–1.76), especially within fronto-temporal regions. MCI subjects also had increased TSPO levels, mainly within the neocortex, with more modest effects (SMD range: 0.46 - 0.90). Meta-regression analysis identified an inverse association between TSPO levels in the parietal region and Mini-Mental State Examination scores, a proxy for disease severity, in AD subjects (estimate: -0.11, 95% confidence interval: −0.21 to −0.02; P = 0.024).ConclusionsOur findings support the association of increased neuroinflammation during the progression of MCI and AD, relative to HCs. |
| |
| Keywords: | Mild cognitive impairment Alzheimer’s disease Neuroinflammation Positron-emission tomography Inflammation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
