Association of CCL11, CCL24 and CCL26 with primary biliary cholangitis |
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| Institution: | 1. Department of General Surgery, Huangyan Hospital of Wenzhou Medical University, Taizhou First People''s Hospital, Taizhou, Zhejiang, China;2. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China;3. Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People''s Hospital, Taizhou, Zhejiang, China;1. Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People''s Hospital, Taizhou, Zhejiang, China;2. Department of general surgery, Huangyan Hospital of Wenzhou Medical University, Taizhou First People''s Hospital, Taizhou, Zhejiang, China;3. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China;1. Medical School of Hebei University, Baoding, China;2. People''s Hospital of Nankai University, Tianjin, China;1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28160, Republic of Korea;2. Department of Pharmaceutical Engineering, Cheongju University, Cheongju, Chungbuk 28503, Republic of Korea;1. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | BackgroundCCL11, CCL24 and CCL26 are potent chemokines for eosinophils. Since there has been no study reporting the association serum CCL11, CCL24 and CCL26 with fibrotic progression of PBC, the aim of this study is to explore the association.MethodsOne hundred and eight PBC patients, 52 patients with chronic hepatitis B (CHB) and 50 healthy controls (HC) were recruited. The sera were detected for CCL11, CCL24 and CCL26 using multiplex immunoassay. Other laboratory indicators were routinely measured. PBC was divided into four stages according to Scheuer's classification.ResultsSerum CCL11, CCL24 and CCL26 levels were significantly higher in PBC patients than those with CHB and HC (P < 0.05). The ROC analyses showed that all of the three CCLs performed well for identification of PBC (all P< or =0.001). The multiple linear regression analysis showed an independent relationship of CCL26 with APRI and FIB-4 in PBC patients, but no relationship of CCL11 and CCL24 with fibrotic indicators. Additionally, serum CCL11 and CCL26 were negatively correlated with histological stage of PBC, while serum CCL24 showed no statistical correlation.ConclusionSerum CCL11, CCL24 and CCL26 are upregulated in PBC. CCL11 and CCL26 are associated with fibrotic progression of PBC, but CCL24 is not. |
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