Factors influencing the bioavailability of fluoride from calcium-rich, health-food products and CaF2 in man

After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from bone-meal, calcium and CaF2 tablets was evaluated in relation to that of NaF. Tablets were administered either whole or as a finely-ground powder, either to fasting subjects or with breakfast. Availability was lowest from whole tablets taken by fasting subjects, and highest from powdered substances given with breakfast. Mean F availabilities ranged between 7.2 and 39 per cent with bone-meal tablets, between 20 and 59 per cent with Ca tablets, and between 0 and 47 per cent with CaF2 tablets.