2型糖尿病患者血清内脏脂肪素水平及其影响因素

目的探讨2型糖尿病（T2DM）患者血清内脏脂肪素水平的变化及其影响因素。方法选择T2DM患者47例，健康对照（NGT）35名，测定受试者一般临床及生化指标，酶联免疫吸附法（ELISA）测定空腹血清内脏脂肪素水平，并分析各指标的关系。结果与NGT组相比，T2DM组内脏脂肪素水平明显升高（70．43±20．710g／Lw98．48±22．37μg／L，P〈0．01）；相关性研究显示，内脏脂肪素水平与腰围、臀围、腰臀比、空腹血糖、HbA1c均呈正相关；多元线性逐步回归分析表明，腰围和空腹血糖是影响内脏脂肪素水平的独立相关因素。结论T2DM患者空腹血清内脏脂肪素水平升高，血清内脏脂肪素可能在T2DM发生发展中起一定的作用。

Serum visfatin level in type 2 diabetes mellitus patients and its influencing factors

Objective To investigate the serum visfatin level in the subjects with type 2 diabetes mellitus （T2DM） and its influencing factors. Methods 47 T2DM patients were selected as T2DM group and 35 healthy subjects, as control group. Body height and weight, waist circumference （WC） and hip circumference （HC）, blood pressure, and fasting levels of glucose, insulin, HbAlc and visfatin were determined in T2DM and control group. Visfatin level was measured with enzyme-linked immunosorbent assay （ELISA）. The HOMA-IR was calculated. The relationships of level of serum visfatin with BMI, WC, WHR, FPG, Fins, HOMA-IR, HbA2c and blood lipids were analyzed. Results The visfatin level of T2DM group versus control group was increased significantly（98.48± 22.37μg/L vs 70. 43 ± 20. 71μg/L,P〈0. 01） and positively correlated with WC（r=0.307, P〈0.01）, HC（r=0.297, P〈 0.01）, WHR（r= 0. 242, P〈0.05）, FPG（r=0.503, P〈0.01）and HbA1c（r= 0. 464, P〈0.01）. Multiple regression analysis showed that WC and FPG were independent related factors for influencing the serum visfatin level. Conclusions The fasting serum visfatin level is increased in T2DM patients, which may contribute, in part, to the pathogenesis of T2DM.